ChemInform Abstract: N1‐Phenyl Substituted 4‐Quinolones of Tuberculostatic Activity.

Abstract

N1-Phenyl Substituted 4-Quinolones of Tuberculostatic Activity. -The N1-phenyl-6-fluoro-7-piperazinyl-4-quinolone 3-carboxylates (I) and the diazoniumtetrafluoroborate of sparfloxacin (II) are tested for their ability to inhibit the growth of Mycobacterium strains. -(HOLZGRABE, U.; STEIN-ERT, M.; Pharmazie 56 (2001) 11, 850-851; Inst. Pharm. Lebensmittelchem.,

The insulinotropic effect of fluoroquinolones

“…A substitution with a mono-or difluorinated aryl moiety at N1 (D) gives compounds with enhanced antituberculotic activity [41]. All of these substituents were found to be compatible with an insulinotropic effect.…”