Breast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyphenols are flavonoids that appear to exhibit properties which are beneficial for breast cancer therapy. Numerous epidemiologic studies have been performed on the dynamic effect of plant polyphenols in the prevention of breast cancer. There are also subclasses of flavonoids that have antioxidant and anticarcinogenic activity. These can regulate the scavenging activity of reactive oxygen species (ROS) which help in cell cycle arrest and suppress the uncontrolled division of cancer cells. Numerous studies have also been performed at the population level, one of which reported a connection between cancer risk and intake of dietary flavonoids. Breast cancer appears to show intertumoral heterogeneity with estrogen receptor positive and negative cells. This review describes breast cancer, its various factors, and the function of flavonoids in the prevention and treatment of breast cancer, namely, how flavonoids and their subtypes are used in treatment. This review proposes that cancer risk can be reduced, and that cancer can be even cured by improving dietary intake. A large number of studies also suggested that the intake of fruit and vegetables is associated with reduced breast cancer and paper also includes the role and the use of nanodelivery of flavonoids in the healing of breast cancer. In addition, the therapeutic potential of orally administered phyto-bioactive compounds (PBCs) is narrowed because of poor stability and oral bioavailability of compounds in the gastrointestinal tract (GIT), and solubility also affects bioavailability. In recent years, creative nanotechnology-based approaches have been advised to enhance the activity of PBCs. Nanotechnology also offers the potential to become aware of disease at earlier stages, such as the detection of hidden or unconcealed metastasis colonies in patients diagnosed with lung, colon, prostate, ovarian, and breast cancer. However, nanoformulation-related effects and safety must not be overlooked. This review gives a brief discussion of nanoformulations and the effect of nanotechnology on herbal drugs.

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Background: Medicinal plants are being manipulated by the variety of methods with genes. Genetic engineering is the alteration of genetic material of an organism via biotechnology techniques. Wide range of genetically modified medicinal plants are diligently examined possessing therapeutic efficacy for the treatment of various diseases, like diabetes, cardiovascular diseases, rheumatoid arthritis, and cancer. Objective: This review discloses the numerous genetically modified herbs employed in the treatment of diseases, such as diabetes, cardiovascular diseases, rheumatoid arthritis, and cancer. In addition, the review highlights the therapeutically active constituents present in these herbs, which are liable for their specific pharmacological action. Methods: Several review, research papers, and patents highlighting the enormous aptitude of genetically modified herbs in the treatment of various diseases were collected from medical databases, and are exhaustively studied for writing this review paper. Results: Due to rapid advancement in the phytochemical investigation of therapeutically active plants, and because of their potential to treat these disorders, they are being rapidly promoted and favoured nowadays. Moreover, a range of active constituents can be isolated from natural plants that can be employed in the treatment of various disorders, and due to their less toxicity they are preferred over synthetic products. Conclusion: Utilizing genetically modified herbs, like Azadirachta indica, Allium cepa, Acacia arabica, Allium sativum, and herbal formulations like flaxseed oil, green tea, and many more appear to be a pioneerstrategy in the therapy of these diseases, but still further investigation is required to overcome the negative outcomes of these herbs.