Herbal bioactives in transdermal drug delivery system

Kaur, Gagandeep; Madaan, Piyush; Verma, Rishu; Chandel, Parteek; Salgotra, Twinkle; Kaur, Harnoor; Sindhu, Rakesh K.

doi:10.1016/b978-0-12-824385-5.00016-9

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Medicinal plants are in a continuous process of exploration, resulting in the unearthing of novel plant-based pharmaceuticals to understand the molecular mechanisms of conventional medication and its active ingredients, which may help the renovation of plant-derived medications and detection of novel phyto-agents [63]. Phytomedicine may include several issues such as using medicinal plants as wound healing agents [64,65], natural anti-microbials from plants [66], herbal therapy or remedies [67], herbal cosmeticology [68], phytopharmaceuticals [69,70], phyto-pharmacology [71] using the herbal bioactivities in drug delivery systems like the ocular [72], pulmonary [73], transdermal [74], and vaginal and rectal drug delivery systems [75]. Therefore, it is very important to know exactly what we eat to stay healthy for a long time as conveyed by the term "nutraceuticals" [76].…”

Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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The Kingdom of Plantae is considered the main source of human food, and includes several edible and medicinal plants, whereas mushrooms belong to the Kingdom of fungi. There are a lot of similar characteristics between mushrooms and higher plants, but there are also many differences among them, especially from the human health point of view. The absences of both chlorophyll content and the ability to form their own food are the main differences between mushrooms and higher plants. The main similar attributes found in both mushrooms and higher plants are represented in their nutritional and medicinal activities. The findings of this review have a number of practical implications. A lot of applications in different fields could be found also for both mushrooms and higher plants, especially in the bioenergy, biorefinery, soil restoration, and pharmaceutical fields, but this study is the first report on a comparative photographic review between them. An implication of the most important findings in this review is that both mushrooms and plants should be taken into account when integrated food and energy are needed. These findings will be of broad use to the scientific and biomedical communities. Further investigation and experimentation into the integration and production of food crops and mushrooms are strongly recommended under different environmental conditions, particularly climate change.

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Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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“…Phytosomes can be prepared using various techniques, including solvent evaporation, thin-film hydration, and coacervation 14 . Solvent evaporation involves dissolving the phytoconstituent and phospholipid in a common solvent and evaporating the solvent to form a thin film 15 . Thin-film hydration hydrates the thin film with an aqueous phase to form liposomes.…”

Section: Introductionmentioning

confidence: 99%

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

Saeed,

Sadr,

Gharib

et al. 2022

J Lab Anim. Res

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Cancer is a life-threatening disease that remains a global health problem, with millions of people diagnosed yearly. Despite significant progress in cancer treatment, conventional chemotherapy still faces several limitations, including poor solubility, low bioavailability, lack of selectivity, and severe side effects. Therefore, alternative therapeutic strategies are necessary to improve cancer therapy. This review aimed to provide an updated overview of phytosome complexes and their potential application in cancer therapy, including their formulation techniques, transportation mechanism through phytosome, and recent investigations on their efficacy in treating different types of cancers. In recent years, nanotechnology has emerged as a promising approach to cancer therapy, as it enables the delivery of therapeutic agents to the tumor site with higher selectivity and efficiency. Phytosomes are a nanotechnology-based drug delivery system conjugating plant extracts or phytoconstituents with phospholipids. This conjugation results in the formation of a complex with improved solubility, stability, and bioavailability. Phytosomes have been shown to enhance the pharmacokinetic profile of phytoactive compounds, allowing for better targeting and sustained release. Phytosomes of curcumin, resveratrol, and quercetin have demonstrated anticancer properties in various in vitro and in vivo models. Moreover, phytosomes have been used to deliver chemotherapeutic agents, such as paclitaxel, docetaxel, and camptothecin, with improved efficacy and reduced toxicity. Phytosome complexes offer a promising platform for cancer therapy due to their ability to enhance the bioavailability and efficacy of phytoactive compounds. Incorporating phytosomes in cancer therapy could lead to the development of more effective and less toxic treatments for different types of cancers. Further studies are needed to elucidate the mechanism of action of phytosomes and to optimize their formulation for clinical use.

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Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles

V. M.,

Suresh,

Kumar

et al. 2023

Journal of Biomaterials Science, Polymer Edition

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Herbal bioactives in transdermal drug delivery system

Cited by 3 publications

References 38 publications

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles

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