We report a case of pseudo-thrombocytopenia due to cold agglutinins against platelets. These cold agglutinins were the cause for diagnostic confusion and resulted in extensive workup and unnecessary therapeutic precautions. A thirty two year old female with Guillain-Barre syndrome was admitted in the ICU and serial work-up showed markedly low levels of platelets. The patient had no symptoms of bleeding and patient was investigated extensively for deciphering the etiology of low platelet count. In-vitro clumping of platelets was suspected and in-vitro studies showed marked clumping of platelets with ethylene-diamine-tetra-acetic acid, citrate and heparinized samples. The manual platelet count was found to be within normal limits. Thrombocytopenia as a result of platelet cold agglutinins is a rare cause of in-vitro low platelet counts. No clinical problems have been reported due to the same.
We report a case of unexplained transient ventricular fibrillation in a child with ventricular septal defect (VSD) scheduled for VSD closure. The bispectral index (BIS) values dropped within 15s of transient cardiac arrest and it showed recovery within 15 s of restoration of circulation. Monitoring BIS during surgery, especially cardiac surgeries may help identify periods of cerebral ischemia early.
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