Aim: To examine the PON1-L55M and -Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers. Methods: Blood samples were collected from 203 women (PCOS [n = 151], control [n = 52]). Genomic DNA was extracted and RFLP method was performed following the amplifications of the target regions. Results: Individuals with 192QR/192RR genotypes had a 2.5-fold increased risk of representing PCOS compared with the individuals with 192QQ genotype. Q192R was more strongly associated with PCOS than previously suggested atherosclerosis risk markers. Q192R status and body mass index values in combination were established to be a significant predictor of PCOS (AUC: 0.655, p = 0.001). Conclusion: This is one of the first studies suggesting the use of combination biomarkers to better predict the risk of developing PCOS.
Purpose:The purpose of our study was to conduct a chemical analysis of extracranial foreign bodies (FBs) causing artifacts in cranial magnetic resonance imaging (MRI) and to investigate the association between chemical composition, magnetic susceptibility, and artifact size.Materials and Methods:A total of 12 patients were included in the study. The FBs responsible for the artifacts were visualized using cranial computed tomography (CT). Artifact-causing FBs were removed from the scalps of 10 patients and analyzed using scanning electron microscope with energy dispersive spectroscopy (SEM-EDS), X-ray diffraction spectroscopy (X-RD), and Fourier-transform infrared spectroscopy (FT-IR). The magnetic susceptibility of the samples was determined using the reference standard material MnCl2.6H2O. The volume of the MRI artifacts was measured in cubic centimeters (cm3).Results:EDS results demonstrated that the mean Fe ratio was 5.82% in the stone samples and 0.08% in the glass samples. Although no phase peaks were detected in the X-RD spectra of the glass samples, peaks of Fe2O3, Al2Ca (SiO4) were detected in the X-RD spectra of the stone samples. The FT-IR spectra revealed metal oxide peaks corresponding to Fe, Al, in the stone samples and peaks confirming Al2SiO5 and Na2SiO3 structures in the glass samples. The mean volumes of the MRI artifacts produced by the stone and glass samples were 5.9 cm3 and 2.5 cm3, respectively.Conclusions:Artifacts caused by extracranial FBs containing metal/metal oxide components are directly associated with their chemical composition and the artifact size are also related to element composition and magnetic susceptibility.
ÖzetAmaç:Onkoloji hastalarında kemoterapi ajanlarının kullanılması, bu hastalarda uygun desteğin de sağlanabileceği santral yolların kullanımını zaruri kılmıştır. Biz girişimsel radyoloji ünitesinde erişkin hastalara başarıyla takılan 498 port kateterin, erken ve geç komplikasyonlarını retrospektif olarak değerlendirdik. Port kateterleri takan ve kullanan sağlık personelinin karşılaşabileceği komplikasyonları öğrenmesini, dikkatli ve hijyenik kullanımının önemini bildirmeyi amaçladık. Gereç ve Yöntem:Çalışmaya girişimsel radyoloji bölümümüzde ultrason ve floroskopi eşliğinde internal juguler ven yoluyla iki yıl boyunca 498 hastaya perkütanöz venöz girişle taktığımız port kataterleri retrospektif olarak erken ve geç komplikasyonlarını değerlendirdik. Port kateter takılan hastaların yaş, cinsiyet, primer tanısı, takılan portun cinsi, anestezinin türü, erken ve geç komplikasyonları, eksplantasyon nedenleri saptandı ve bilgisayar ortamına kaydedildi. İşlemden sonraki 2 hafta içerisindeki komplikasyonlar erken, daha sonraki komplikasyonlar geç olarak kabul edildi. Bulgular:Hastaların 195'i kadın (%39,2), 303'ü erkekti (%60,8). Hastaların asıl tanılarına bakıldığında en büyük grubu 413 hasta (%82,9) ile gastrointestinal sistem maligniteleri oluşturmuştu. Başarıyla yerleştirdiğimiz tüm port kateterlerimizde pnömotoraks, yanlış arteryel giriş, pleksus irritasyonu ve hava embolisi gibi erken major komplikasyonlar gelişmedi. Sadece 3 vakada erken dönemde hematom gelişti. Geç komplikaslarımızın oranı %3,4 idi. Sonuç:Major erken komplikasyonlar olmaksızın görüntüleme kılavuzluğunda gögüs duvarına yerleştirilen port kateterlerin, düşük komplikasyon oranına sahip olması nedeniyle cerrahi tekniğe göre üstünlük göstermektedir. Retrospective evaluation of 498 venous access port implantations and complications in adult patients. Anahtar Kelimeler:Ultrasonografi, floroskopi, port kateter. Eldeş T, Akmangit İ, Dede D, Yıldırım N, Sayın B, Polattaş P. Erişkin hastalarda 498 deri alti port kateter uygulamalari ve komplikasyonlarinin retrospektif değerlendirilmesi. Pam Tıp Derg 2019;12:209-214. AbstractPurpose:Application of chemotherapy agents in oncology cases has necessitated the use of central routes to provide appropriate support for these patients. We retrospectively evaluated the early and late complications of 498 port catheters successfully implanted in adult patients in our interventional radiology unit. We aimed to inform health personnel that implant and use port catheters about possible complications and emphasize the importance of careful and hygienic use of these materials. Materials and Methods:Over two years, we retrospectively evaluated the early and late complications of port catheters implanted in 498 patients through ultrasound-and fluoroscopy-guided internal jugular venous and percutaneous venous access in our interventional radiology department. Age, sex, primary diagnosis, type of port implanted, type of anesthesia, early and late complications, and reasons for explantation were determined and recorded in a comp...
The aim of this study was to investigate the contribution of quantitative apparent diffusion coefficient (ADC) measurements in the diagnosis of testis torsion. Material and Methods: The study included 28 patients that underwent a magnetic resonance imaging (MRI) scan between January 2013 and June 2017 due to acute scrotal pain. Definitive diagnosis was based on the symptom assessment, treatment, and follow-up of the patients. Based on these parameters, patients were categorized into groups and quantitative ADC values were compared among these groups. Results: Of the patients included in the study, 9 were diagnosed with epididymitis, 9 with orchitis, and 10 with testis torsion. The mean ADC values in the affected testes of testis torsion, epididymitis, and orchitis groups were 0.763 ± 0.154 X 10-3 mm 2 /s, 1.050 ± 0.850 X 10-3 mm 2 /s, and 1.105 ± 0.218 X 10-3 mm 2 /s, respectively. The mean ADC values of the affected testes were significantly lower in the testis torsion group compared to the other groups (p<0.01). In the testis torsion group, the mean ADC value of the affected testes was significantly lower compared to the unaffected testes (0.763 ± 0.154 X 10-3 mm 2 /s vs 1.053 ± 0.147 X 10-3 mm 2 /s, p<0.05, respectively).
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