Due to the harsh climatic conditions in high altitude and cold regions with large temperature differences, asphalt pavement is generally prone to cracking, and the cracks propagate rapidly, which reduces the service life and service level of the road. The factors influencing the fracture characteristics of asphalt mixtures were analyzed in this paper, and the mixtures with different aggregate gradations from various types of asphalt were prepared. The fracture characteristics were explored using the thermal stress restrained specimen test (TSRST) and low-temperature bending test, and the good consistency of the low-temperature fracture performance was identified according to the results of frost-break temperature, flexural strength, and fracture toughness. The frost-break temperature was confirmed as the best indicator of the material crack resistance and could be used as the index to evaluate the performance of asphalt mixtures at low temperatures. The frost-break temperature of matrix asphalt mixture is 8–10 °C higher than that of modified asphalt mixture, and AC asphalt mixture is 2–4 °C higher than that of SMA asphalt mixture. The excellent asphalt performance has a more important influence on the fracture characteristics of asphalt mixture. The asphalt mixture of the same type had similar fracture toughness at varying notch depths, the most deviation is 3.78% which shows that the initial crack depth has little effect on the fracture toughness of asphalt mixture at low temperature. The results of the study can provide a basis for the selection of asphalt pavement surface materials and the optimization of mixtures in high altitude and cold regions with large temperature differences.
This study explores the temperature changes and freeze–thaw cycles in certain typical high-altitude areas, finding that these areas encounter more than 120, or even more than 200, freeze–thaw cycles per year. Such frequent freeze–thaw cycles deliver significant impact on the performance of asphalt pavements, with cracks becoming a typical problem in high-altitude areas. Such factors as cold weather, large temperature differences, and frequent freeze–thaw cycles have adverse effects on the stress of asphalt pavement materials, resulting in cracks in pavements. By simulating the conditions of such frequent freeze–thaw cycles, this study explores the law of changes in the performance of roads made from asphalt and asphalt mixtures, as well as the low-temperature crack resistance properties of asphalt and asphalt mixtures in frequent freeze–thaw cycles. It is found that the performance of the three different types of asphalt binders used in the test shows basically no change after 50 freeze–thaw cycles, and the asphalt types have a significant effect on the low-temperature performance of asphalt mixtures. The modified asphalt shows a higher viscosity than the matrix asphalt, with better toughness than that of the matrix asphalt at low temperature. Frequent freeze–thaw cycles significantly influence the low-temperature splitting tensile strength and water stability of asphalt mixtures; with increased freeze–thaw cycles, the splitting strength and freeze–thaw splitting tensile strength ratio will gradually decrease to a significant level. The freeze–thaw conditions are found delivering remarkable influence on the low-temperature splitting tensile strength and water stability of asphalt mixtures. The research results of this study provide a basis for the selection of asphalt pavement materials as well as the optimal design of mixtures in high-altitude area like the Qinghai-Tibet Plateau.
Background: Dominant mutations in MYO7A may lead to nonsyndromic deafness DFNA11. A p.R206C variant in MYO7A has previously been reported in a small deaf family from Taiwan but with ambiguous pathogenicity and inheritance pattern. Aims/Objectives: Our study aims to clarify the pathogenicity of this variant by clinical characterization and genetic analysis of a separate autosomal dominant deaf family harboring this variant in mainland China. Materials and Methods: Auditory features of hearing loss were characterized in representative affected family members. Mutation screening was performed by targeted next-generation sequencing of 138 known deafness genes in the proband. Candidate pathogenic mutations were confirmed by Sanger sequencing in family members and ethnically matched controls. Results: Consistent with typical DFNA11 phenotype, the affected family members in this study showed delayed-onset, progressive hearing loss affecting mostly high frequencies. Targeted next-generation sequencing identified a p.R206C mutation in MYO7A as the only candidate pathogenic mutation cosegregating with the hearing phenotype. This mutation is not seen in 200 Chinese Han normal-hearing controls. Conclusions and Significance: The
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