A well encapsulated round tumor was found in the kidney nephrectomized from a young hypertensive woman. The main body of the tumor was composed of small vessels similar in caliber to the glomerular afferent arterioles and polygonal cells derived from them inbetween. These cells contained characteristic granules demonstrable by the Bowie's procedure. Histological assumption of a renin-producing tumor was substantiated by the demonstration of plasma renin activities before and after the surgery. The patient's blood pressure returned immediately to normal after nephrectomy. A term of "juxtaglomerular cell tumor" was proposed to this hitherto unreported tumor. ACTA PATH. JAP. 18: 197-206, 1968.
SUMMARY Myocardial fiber diameters were measured to determine their distribution throughout the ventricular wall in normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy (1HCM). In normal a'dult hearts and hypertensive hearts, the diameter decreased from the inner to the outer third of the left ventricular free wall and from the left ventricular side to the right ventricular side of the septum. In HCM, these regional differences were preserved in the left ventricular free wall, but not in the septum. The diameter was greatest in the middle third of the septum, where myocardial fiber disarray was widely distributed. The diameters of the fibers in the right ventricular side of the septum were significantly larger than those of the fibers in the left ventricular side of the septum in HCM. This finding, in contrast to that in normal adult hearts or hypertensive hearts, was considered to be related to the inward convex curvature of the left ventricular chamber. Although there was no significant difference in the diameter of myocardial fibers in the left ventricular free wall between hypertensive hearts and hearts with HCM, the diameters of those in the right ventricular free wall, in the right ventricular side of the septum and in the middle third of the septum were significantly larger in HCM than in hypertensive hearts. We conclude that there is a transmural variation of myocardial fiber diameter in the left ventricuar free wall and the ventricular septum, and such transmural variation in HCM is clearly different from that in hypertensive hearts.THE DIAMETERS of myocardial fibers in various heart diseases and in different regions of the heart have been recorded. However, little information is available on the regional variations throughout the ventricular wall. Studies on the regional distribution of intramyocardial pressure7-' and ventricular stress"-'2 lead one to expect that the diameter of myocardial fibers varies with their depth in the ventricular wall from the endocardial to the epicardial layers.Since the initial description by Brock,"3 there have been several reports of hypertrophic cardiomyopathy (HCM) coexisting with systemic hypertension. 1416 Moreover, asymmetric septal hypertrophy, which is one of the characteristic features of HCM, is not uncommon in patients with systemic hypertension.'719 Therefore, a differentiation between these two entities is clinically important when asymmetric septal hypertrophy coexists with systemic hypertension.In the present study we measured the diameters of myocardial fibers in different regions of the heart to determine the differences in their distribution throughout the ventricular wall in normal hearts, hypertensive hearts and hearts with HCM. trophy due to hypertension and 11 hearts with HCM.The age, sex and heart weights of the subjects are listed in table 1. A heart was considered normal if it had no evidence of clinical heart disease, the coronary arteries did not show more than 75% luminal narrowing and the heart weighed less t...
The MIBG washout rate of the spasm-induced coronary artery territory changed according to the degree of disease activity. Thus, sympathetic nerve activity could reflect disease activity of vasospastic angina.
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