Osteoporosis means "Porous bone" is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India. Alendronate (Aln) is a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclast cells. Alendronate-sodium is a BCS class III bisphosphonate, used in the treatment of osteoporosis, acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Alendronate was the first bisphosphonate to be approved for osteoporosis in the US in 1995.The objective of the present study is to develop, optimize, and evaluate Alendronate-loaded chitosan nanoparticles (NPs) for the treatment of osteoporosis. NPs were prepared by the Ionic gelation method and optimized for various parameters. The prepared nanoparticles were characterized using particle size analyser (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and fourier-transform infrared spectroscopy (FTIR). Formulated NPs were obtained in the average size ranging from 60 nm to 220 nm in TEM, SEM and DLS studies. The release profile was depended on the dissolution medium. The proposed nanoparticles offer an interesting alternative for alendronate delivery via the oral route. Our results indicated that alendronate-loaded chitosan nanoparticles provide an effective medication for the treatment of osteoporosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.