Summary To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of three genome-wide association studies (GWAS) and two independent datasets genotyped on the Immunochip, involving 10,588 cases and 22,806 controls in total. We identified 15 new disease susceptibility regions, increasing the number of psoriasis-associated loci to 36 for Caucasians. Conditional analyses identified five independent signals within previously known loci. The newly identified shared disease regions encompassed a number of genes whose products regulate T-cell function (e.g. RUNX3, TAGAP and STAT3). The new psoriasis-specific regions were notable for candidate genes whose products are involved in innate host defense, encoding proteins with roles in interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C), and NF-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

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Objective: To compare the efficacy of narrowband UV-B (TL-01) phototherapy with oral 8-methoxypsoralen photochemotherapy (8-MOP psoralen-UV-A [PUVA]) in patients with chronic plaque psoriasis (CPP).

Conclusion. These data suggest that OSM promotes angiogenesis and endothelial cell migration and potentiates the effects of IL-1␤ in promoting extracellular matrix turnover and human cartilage degradation. Furthermore, the induction of VEGF in cocultures supports the hypothesis of a link between angiogenesis and cartilage degradation.Rheumatoid arthritis (RA) is a chronic disease characterized by synovial tissue proliferation and articular cartilage degradation (1,2). In RA, angiogenesis is an early event required for pannus development, enabling activated monocytes to enter the synovium via endothelial cells by active recruitment (3). The new vessels support expansion of the synovial pannus over the cartilage, facilitating RA synovial fibroblast (RASF) invasion and cartilage degradation by proteolytic cleavage of both aggrecan and collagen (4). This process depends on cytokines and growth factors to stimulate cell survival, proliferation, and extracellular matrix (ECM) degradation (5). Erosion is characterized by a loss of ECM by overexpression of matrix metalloproteinSupported by the Health Research Board of Ireland.