The glucose tolerance test (GTT) was performed on 722 pregnant women to evaluate the diagnostic criteria for gestational diabetes mellitus (GDM) by the 75 g GTT. The upper limits of the normal levels of plasma glucose were defined as 100 mg/dl, 180 mg/dl and 150 mg/dl at fasting and 1 and 2 hours after glucose loads, respectively. The individuals were termed GDM if 2 or more values were greater than the upper limit at each time point. The incidence of GDM based on our criteria was 3.3% of all subjects. The insulinogenic indices were low and hemoglobin Ale levels were high in the women with GDM. The incidence of fetal and neonatal complications born to mothers with GDM was high. The patients diagnosed as GDM in the present study appeared to show certain differences in clinical features compared to pregnant women with normal glucose tolerance.
Summary : The 75 g GTT was performed on 722 pregnant women to clarify the glucose tolerance during pregnancy. The results were as follows : (1) Plasma glucose values after 75g GTT were the same in category A (with potential diabetes or glycosuria) before and after 28 weeks of pregnancy, but for women in categories B (without potential diabetes and glycosuria) and C (excluding the neonatal complications in category B), the plasma glucose values were higher during or after 28 weeks of pregnancy than before the 28th week. (2) The plasma glucose after glucose loading was higher in category A than in category B or C, but there was no difference between category B and C. (3) The plasma insulin values in category B were the same before and after 28 weeks of pregnancy; but for women in categories A and C, the values were significantly higher after 28 weeks of pregnancy.(4) The incidence of a low insulinogenic index was 12.1% in category A, which was significantly higher than the indexes for categories B and C. These results may be useful to establish the normal limit of glucose values after 75g glucose loading during pregnancy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.