The inclusion complex-forming ability of three glucosyl-cyclodextrins (CDs), 6-O-ƒ¿-Dglucosyl-ƒ¿-CD (G-ƒ¿-CD), 6-O-ƒ¿-D-glucosyl-ƒÀ-CD (G-ƒÀ-CD), and 6A,6D-di-O-ƒ¿-D-glucosyl-ƒÀ-CD (2G-ƒÀ-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes with the parent CDs. The enhancement of solubility of poorly water-soluble drugs by glucosyl-ƒÀ-CDs was much more marked than that by fl-CD. The hemolytic activity of glucosyl-CD was lower than that of each parent CD. The estriol-glucosyl-ƒÀ-CD complex may be practically applicable to injectable preparations because of its high water-solubility and low hemolytic activity.
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