Adenosine A2a receptors are found in the endothelia, vascular smooth muscle cells and cardiac myocytes. The properties of a carbon-11 labeled A2a antagonist [11C]KF17837 ([7-methyl-11C](E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methy lxa nthine) for myocardial imaging were evaluated by dynamic PET scanning of the myocardium in rabbits. Myocardial uptake of [11C]KF17837 was clearly visualized by PET. The tracer was taken up at a high level by the myocardium immediately after the injection, and the myocardial level of radioactivity gradually decreased. On the other hand, an inactive [11C]Z-isomer of [11C]KF17837 showed a very low myocardial uptake and the myocardium was not visualized with a selective A1 antagonist [11C]KF15372. By co-injection with carrier KF17837 or a xanthine type A2a antagonist 7-chlorostyrylcaffeine (CSC), the myocardial uptake of [11C]KF17837 was completely blocked. The effect of non-xanthine A2a antagonists ZM 241,385 and SCH 58,261, which have a higher affinity than CSC, was smaller than that of the CSC. The effect of weak antagonists caffeine and alloxazine or a xanthine type A1 antagonist KF15372 on the radioactivity level was small. It is concluded that PET with [11C]KF17837 can image myocardial adenosine A2a receptors.
Aim
To evaluate the feasibility, acceptability, and outcome of the Adaptation Support Program in Early Pregnancy after the use of assisted reproductive technology (ART).
Methods
The participants were 57 primiparas who had undergone ART and had received the Adaptation Support Program. The data were gathered by using questionnaires before (Time 1), immediately after (Time 2), and 8 weeks after (Time 3) the intervention between August, 2014 and March, 2015. The data for the 40 women who gave valid answers were analyzed statistically.
Results
Of the respondents, 75% gave a positive evaluation that the program met their expectations and >80% positively evaluated it for its convenience, problem‐solving intentionality, satisfaction, and usefulness. The Anticipatory Anxiety for Loss Scale (AALS) and State–Trait Anxiety Inventory (STAI‐J) scores decreased significantly at Times 2 and 3 and the Edinburgh Postnatal Depression Scale (EPDS) scores at Time 3. The Post‐traumatic Growth Inventory‐Japanese (PTGI‐J) scores, showing growth as a result of infertility experience, increased significantly at Time 3. The Care Need Satisfaction Scale (CNSS) scores showed a positive correlation with the PTGI‐J scores and negative correlations with the AALS and STAI‐J, but did not correlate with the EPDS.
Conclusion
This program was evaluated positively. The AALS, PTGI‐J, EPDS, and STAI showed significant change after the program and the AALS, PTGI‐J, and STAI‐J showed significant correlations with the CNSS.
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