No abstract

A stereoselective method for synthesis of trans-2,3-disubstituted 2,3-dihydropyrroles is reported. N-Sulfonyl-1,2,3-triazoles prepared from terminal alkynes generate α-imino rhodium carbene complexes, which when combined with α,β-unsaturated aldehydes produce trans-2,3-disubstituted dihydropyrroles. The method can be successfully applied to a one-pot process starting from terminal alkynes.

No abstract

A 75-year-old man was diagnosed as having a sessile tumor measuring 1.4 x 1.0 cm in size in the duodenal bulb after upper gastroduodenal series. The biopsy specimens revealed a proliferation of the adenomatous glands showing an acinar structure with papillary infolding; type III mucus, which is characteristic of Brunner's glands. Antral glands and mucus neck cells of the fundic glands were also observed in the adenomatous glands by concanavalin A staining. Thus, it was clear that the tumor had originated from the Brunner's glands. Three years and four months later, the sessile tumor had developed into a fungating ulcerated tumor via a polypoid form. The biopsy specimens revealed a papillary adenocarcinoma with foci of undifferentiated carcinoma. Retrospectively, the adenomatous glands in the biopsy taken from the sessile tumor should have been regarded as low grade carcinoma. Therefore, we propose that when a polyp or tumor shows an increase in size or change in macroscopic appearance, surgery should be considered.

The Median Tectonic Line (MTL) is the longest arc-parallel fault system in southwest Japan whose right-lateral strike-slip is related to oblique subduction of the Philippine Sea plate (PH). We constructed a dense Global Positioning System network along a 200 km-long traverse line across the MTL in 1998 to estimate deep fault structure and slip distribution. Horizontal velocities were determined at 65 sites through campaign measurements and show crustal shortening in the direction of the plate convergence. Using multi-rectangular segments and depthdependent coupling at the plate interface, we calculate and remove elastic deformation caused by the PH subduction. The residual velocity field shows right-lateral strike-slip block motion of about 5 mm/yr across the MTL, consistent with geological estimates. However, the block boundary does not coincide with the surface trace of the MTL, being displaced 20-30 km to the north. The residual velocity field is reproduced by a model with a 35-45• northwarddipping fault plane, full locking of the upper portion to a depth of 15 km, and steady slip of 5 mm/yr below. GPS results are supported by imaging of an inclined fault plane revealed by seismic profiling and currently low activity of shallow earthquakes.