Novel organic-inorganic hybrid nanoparticles with a bisphenol A (BPA)-responsive hydrogel layer on the surface of SiO 2 nanoparticles were prepared via surface-initiated atom transfer radical polymerization of acrylamide (AAm), acryloyl-modified β-cyclodextrin (CD) and N, N′-methylenebisacrylamide. The resulting CD-PAAm/SiO 2 nanoparticles underwent a change in size in response to BPA. The BPA-responsive shrinkage of the CD-PAAm/SiO 2 nanoparticles was caused by an increase in the crosslinking density of the CD-PAAm hydrogel layer, which resulted from the formation of CD-BPA-CD complexes acting as dynamic crosslinks. The smart functions of BPA-responsive organic-inorganic hybrid nanoparticles can provide useful tools for constructing molecular sensors and adsorption materials.
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