We describe initial results of miRNA sequence analysis with the optimal symbol compression ratio (OSCR) algorithm and recast this grammar inference algorithm as an improved minimum description length (MDL) learning tool: MDLcompress. We apply this tool to explore the relationship between miRNAs, single nucleotide polymorphisms (SNPs), and breast cancer. Our new algorithm outperforms other grammar-based coding methods, such as DNA Sequitur, while retaining a two-part code that highlights biologically significant phrases. The deep recursion of MDLcompress, together with its explicit two-part coding, enables it to identify biologically meaningful sequence without needlessly restrictive priors. The ability to quantify cost in bits for phrases in the MDL model allows prediction of regions where SNPs may have the most impact on biological activity. MDLcompress improves on our previous algorithm in execution time through an innovative data structure, and in specificity of motif detection (compression) through improved heuristics. An MDLcompress analysis of 144 over expressed genes from the breast cancer cell line BT474 has identified novel motifs, including potential microRNA (miRNA) binding sites that are candidates for experimental validation.
Quantum computing is an interdisciplinary field that lies at the intersection of mathematics, quantum physics, and computer science, and finds applications in areas including optimization, machine learning, and simulation of chemical, physical, and biological systems. It has the potential to help solve problems that so far have no satisfying method solving them, and to provide significant speedup to solutions when compared with their best classical approaches. In turn, quantum computing may allow us to solve problems for inputs that so far are deemed practically intractable. With the computational power of quantum computers and the proliferation of quantum development kits, quantum computing is anticipated to become mainstream, and the demand for a skilled workforce in quantum computing is expected to increase significantly. Therefore, quantum computing education is ramping up. This article describes our experiences in designing and delivering quantum computing workshops for youth (Grades 9-12). We introduce students to the world of quantum computing in innovative ways, such as newly designed unplugged activities for teaching basic quantum computing concepts. We also take a programmatic approach and introduce students to the IBM Quantum Experience using Qiskit and Jupyter notebooks. Our contributions are as follows. First, we present creative ways to teach quantum computing to youth with little or no experience in science, technology, engineering, and mathematics areas; second, we discuss diversity and highlight various pathways into quantum computing from quantum software to quantum hardware; and third, we discuss the design and delivery of online and in-person motivational, introductory, and advanced workshops for youth.
We describe initial results of miRNA sequence analysis with the optimal symbol compression ratio (OSCR) algorithm and recast this grammar inference algorithm as an improved minimum description length (MDL) learning tool: MDLcompress. We apply this tool to explore the relationship between miRNAs, single nucleotide polymorphisms (SNPs), and breast cancer. Our new algorithm outperforms other grammar-based coding methods, such as DNA Sequitur, while retaining a two-part code that highlights biologically significant phrases. The deep recursion of MDLcompress, together with its explicit two-part coding, enables it to identify biologically meaningful sequence without needlessly restrictive priors. The ability to quantify cost in bits for phrases in the MDL model allows prediction of regions where SNPs may have the most impact on biological activity. MDLcompress improves on our previous algorithm in execution time through an innovative data structure, and in specificity of motif detection (compression) through improved heuristics. An MDLcompress analysis of 144 over expressed genes from the breast cancer cell line BT474 has identified novel motifs, including potential microRNA (miRNA) binding sites that are candidates for experimental validation.
Within the present manuscript we explore the role of skin tone on playing position within English football's top four professional leagues. Player data (N = 4,515) was collected across five seasons (2010)(2011)(2012)(2013)(2014)(2015). Results indicate that in general, darker skin toned players are more likely to operate within peripheral rather than central positions. Using both one and two-way ANOVAs, results suggest significant differences between skin tone and individual playing positions. Between league differences were, however, non-significant. Although darker skin toned players are still more likely to occupy peripheral positions, the situation is more nuanced than first thought. Instead of segregating players by central versus peripheral roles, it appears that darker skin toned players occupy positions associated with athleticism. In contrast, lighter skin toned players appear to fulfill roles requiring organization and communication skills.
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