Haikonen. hf. and T. Räsänen. Hjdmgen ion concentration in the gstiic juice after pylurus ligation in dexamethason‐treated rot. Acta physiol. scand. 1963. 65. 378–382. — Rats were injected with dexaniethasone 3 × 1 mg at 12‐hr intervals before ligation of the pylorus. The hydrogen ion concentration of the gastric secreta. the volume of secretion and the amount of free HCI were measured 2 hrs after tying the ligature. The administration of dexaniethasone for 2 days before ligation of the pylorus inhibited gastric secretion during the ligation and elevated the pH of the secreta. No free HCl was demonstrated in it. Secretion was restored by histamine injected into the rats in connection with the application of the ligature. A single dose of dexamethasone 2 hrs before the application of the ligature caused elevation of gastric secretion.
It is suggested that the degranulation of the mast cells of the gastric Iiiucosa during dexamethasone therapy leads to inhibition of gastric secretion with the mucosa losing the histamine needed for its stimulation. This loss may he compensated by exogenous histamine. On the other hand. the histamine‐liberating property of dexamethasone enhances secretion when the de‐granulation of the mast cdls begins.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.