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Previous analyses of aortic displacement and distension using computed tomography angiography (CTA) were performed on double-oblique multi-planar reformations and did not consider through-plane motion. The aim of this study was to overcome this limitation by using a novel computational approach for the assessment of thoracic aortic displacement and distension in their true four-dimensional extent. Vessel segmentation with landmark tracking was executed on CTA of 24 patients without evidence of aortic disease. Distension magnitudes and maximum displacement vectors (MDV) including their direction were analyzed at 5 aortic locations: left coronary artery (COR), mid-ascending aorta (ASC), brachiocephalic trunk (BCT), left subclavian artery (LSA), descending aorta (DES). Distension was highest for COR (2.3 ± 1.2 mm) and BCT (1.7 ± 1.1 mm) compared with ASC, LSA, and DES (p < 0.005). MDV decreased from COR to LSA (p < 0.005) and was highest for COR (6.2 ± 2.0 mm) and ASC (3.8 ± 1.9 mm). Displacement was directed towards left and anterior at COR and ASC. Craniocaudal displacement at COR and ASC was 1.3 ± 0.8 and 0.3 ± 0.3 mm. At BCT, LSA, and DES no predominant displacement direction was observable. Vessel displacement and wall distension are highest in the ascending aorta, and ascending aortic displacement is primarily directed towards left and anterior. Craniocaudal displacement remains low even close to the left cardiac ventricle.

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The visual and mechanical quality of paperboard packaging components formed by deep drawing closely corresponds to the wrinkle distribution within the material wall section. Assessing this quality of paperboard packaging components currently relies on very slow or even subjective methods. Therefore, counting the number of wrinkles and measuring the mean distance between wrinkles proved to be a sensitive strategy for the evaluation of quality levels in deep drawing formed paperboard containers like cups or trays. A method introduced by Hauptmann proposes the measurement of the distances between 10 wrinkles in machine direction and 10 wrinkles in cross direction for each sample. However, this method is unsatisfactory because it can only observe a small part of each sample and is subject to deviation through the individual judgement of the person carrying out the survey. Further methods, as well as their respective application range, are listed in Table . Hence, it is desirable to automate the wrinkle survey to be carried out without operator influences to the measurement. This paper introduces such an automated measuring method. The given method relies on recording the sample surface topography through laser‐distance measurement. An evaluation algorithm, which enables the detection of wrinkles in the topographic data, is proposed. Furthermore, it is shown that the method yields feasible results and is capable of generating reliable quality information in considerably reduced time frames.

Alexithymia is characterized by a reduced ability to identify and differentiate emotional aspects of social interaction. In this study we investigated, for the first time, whether alexithymia impairs facial mimicry in response to dynamic naturalistic facial affect expressions. Potential volunteers were recruited by means of an online survey (N = 3503). Based on their Toronto Alexithymia Scale-20 sum-score (TAS-20) probands were assigned to an alexithymic group (AG; M = 58.11, SD = 4.58) or a nonalexithymic healthy control group (HC; M = 32.05, SD = 5.56). Both groups were matched by age, gender, and education. All probands were shown digitally generated naturalistic video sequences of faces displaying the basic affects of fear, sadness, disgust, anger, and joy. During the presentation, the participants' facial mimicry responses were recorded by registering the electromyographic (EMG) activity of the corrugator supercilii and zygomaticus major muscles. Overall, the alexithymic probands showed a significantly lower facial EMG activity in response to the affective faces compared to HC. The results thus suggest that alexithymia is associated with a reduced facial mimicry. We discuss the implications of these findings from the perspective of alexithymic impairments within social interaction and the consideration for psychotherapeutic treatment.

In nature, microorganisms often reside in symbiotic co-existence providing nutrition, stability, and protection for each partner by applying "division of labor." This principle may also be used for the overproduction of targeted compounds in bioprocesses. It requires the engineering of a synthetic co-culture with distributed tasks for each partner. Thereby, the competition on precursors, redox cofactors, and energy-which occurs in a single host-is prevented. Current applications often focus on unidirectional interactions, that is, the product of partner A is used for the completion of biosynthesis by partner B. Here, we present a synthetically engineered Escherichia coli co-culture of two engineered mutant strains marked by the essential interaction of the partners which is achieved by implemented auxotrophies. The tryptophan auxotrophic strain E. coli ANT-3, only requiring small amounts of the aromatic amino acid, provides the auxotrophic anthranilate for the tryptophan producer E. coli TRP-3. The latter produces a surplus of tryptophan which is used to showcase the suitability of the co-culture to access related products in future applications. Co-culture characterization revealed that the microbial consortium is remarkably functionally stable for a broad range of inoculation ratios. The range of robust and functional interaction may even be extended by proper glucose feeding which was shown in a two-compartment bioreactor setting with filtrate exchange. This system even enables the use of the co-culture in a parallel two-level temperature setting which opens the door to access temperature sensitive products via heterologous production in E. coli in a continuous manner.

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