Laser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol was investigated in air and argon atmospheres. The characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C2 Swan band systems were observed. The relative hardness of all drug samples was measured as well. Principal component analysis, a multivariate method, was applied in the data analysis for demarcation purposes of the drug samples. The CN violet and C2 Swan spectral radiances were investigated for evaluation of a possible correlation of the chemical and molecular structures of the pharmaceuticals. Complementary Raman and Fourier-transform-infrared spectroscopies were used to record the molecular spectra of the drug samples. The application of the above techniques for drug screening are important for the identification and mitigation of drugs that contain additives that may cause adverse side-effects.
Problem statement: Ethanol production from sugarcane molasses generate large volume of effluent containing high Biological Oxygen Demand (BOD) and Chemical Oxygen Demand (COD) along with melanoidin, a color compound generally produced by "Millard reaction". Melanodin is a recalcitrant compound degraded by specific microorganisms having ability to produce mono and dioxygenases peroxidases, phenoxidases and laccases, are mainly responsible for degradation of complex aromatic hydrocarbons like color compound. These compounds causes several toxic effects on living system, therefore may be treated before disposal. Approach: The purpose of this study was to isolate a potential thermotolerant melanoidin decolorizing bacterium from natural resources for treatment of distillery effluent at industrial level. Results: Total 10 isolates were screened on solid medium containing molasses pigments. Three potential melanoidin decolorizing thermotolerant bacterial isolates identified as Bacillus subtilis, Bacillus cereus and Pseudomonas sp. were further optimized for decolorization at different physico-chemical and nutritional level. Out of these three, Bacillus subtilis showed maximum decolorization (85%) at 45°C using (w/v) 0.1%, glucose; 0.1%, peptone; 0.05%, MgSO 4 ; 0.01%, KH 2 PO 4 ; pH-6.0 within 24h of incubation under static condition. Conclusion/Recommendations: The strain of Bacillus subtilis can tolerate higher temperature and required very less carbon (0.1%, w/v) and nitrogen sources (0.1%, w/v) in submerged fermentation. It can be utilized for melanoidin decolorization of distillery effluent at industrial scale.
Mauriac syndrome is one of the complications of poorly controlled diabetes mellitus type 1. Common presenting features include short stature, growth retardation, moon facies, protuberant abdomen, and proximal muscle wasting. We hereby report a case of 15 year old female who presented with clinical featues of Mauriac syndrome.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.