More and more attention is focused on monodispersed, functionalized microspheres with tunable size. In this article, a facile, efficient self‐assembly process is successfully developed to fabricate novel monodispersed microspheres based on hybrid polyphosphazene, and the size of the microspheres is proven to be easily tailorable. The polymer exhibits excellent thermal and intrinsically fluorescent properties which make up the deficiency of generally fluorescent material prepared by embedding with quantum dots or dyes in some special domains. In addition, a broad ultraviolet‐visible absorption is observed from 300 to 450 nm, and all these superior properties may result in potential applications in ablation‐resistant materials, solar energy photoelectric materials and biomaterials.
Micro or nanoparticles with hollow interiors are receiving immense attention owing to their unique hollow structure and wide application potential. A novel hollow bowl‐shaped microsphere based on a polyphosphazene material is successfully fabricated for the first time by a facile solvent‐treatment process. Based on SEM and TEM observations, the obtained particle is proven to be uniform with a shell thickness of about 120 nm, and a tentative formation mechanism is suggested. By combination of the unique bowl‐shaped structure, uniform microsize, and the superior properties of the hybrid polyphosphazene material, the products are envisioned to have promising applications in microreactors to fabricate functional composite particles, in catalysis, or the biomedical domain.
Background Hypertension is the main risk factor for hemorrhagic stroke. Aldehyde dehydrogenase 2 (ALDH2) may inhibit the occurrence of hypertension by anti-oxidative stress and vascular dilation. The purpose was to investigate the relationship of ALDH2 polymorphisms with hemorrhagic stroke in Hakka Chinese. Methods A total of 329 patients with hemorrhagic stroke and 515 controls were enrolled, and medical records (smoking and drinking history, hypertension, and diabetes) were collected. The genotypes of ALDH2 rs671 of the two groups were detected and analyzed. Results The proportion of the ALDH2 rs671 G/G, G/A, and A/A genotype in patients with hemorrhagic stroke was 55.9%, 37.4%, and 6.7%, respectively, while those were 65.0%, 30.7%, and 4.3% in controls, respectively. There was statistically significant difference in ALDH2 rs671 genotypes distribution ( P =0.021) and alleles distribution ( P =0.005) between patients and controls. Among hemorrhagic stroke patients, no statistically significant differences were observed between patients with ALDH2 different genotypes. Logistic regression analysis showed that there was significantly high risk of hemorrhagic stroke in men (male vs female: adjusted OR 1.711, 95% CI 1.154–2.538, P =0.008), the presence of hypertension (with vs without hypertension: adjusted OR 16.095, 95% CI 10.958–23.641, P <0.001), and the presence of ALDH2 rs671 G/A genotype (G/A vs G/G: adjusted OR 1.679, 95% CI 1.151–2.450, P =0.007) or A/A genotype (A/A vs G/G: adjusted OR 2.516, 95% CI 1.132–5.591, P =0.024). Conclusion ALDH2 rs671 polymorphism likely a risk factor for hemorrhagic stroke.
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