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A novel method of electrochemical methylation-specific ligation detection reaction is first presented for simultaneous evaluation of multiple gene-methylation loci in a single-tube experiment without PCR amplification or restriction enzyme reaction.

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The Solid (Social Linked Data) project focuses on data sharing and privacy security and aims to build a decentralized ecosystem that radically changes the way web applications work today. Our goal is to introduce a ''trust access authentication system'' to achieve secure authentication and fine-grained access control, thereby promoting the implementation of Solid. Blockchain, equipped with multiple security properties and authentication functions, is a crucial technology. In this paper, we present a blockchainassisted system for secure authentication in Solid and for implementation of fine-grained access control policies. Specifically, we explore to integrate threshold RSA signatures in a permissioned blockchain system to enable a fault-tolerant distributed signature scheme, thereby enhancing the resilience and robustness of authentication system. Moreover, we utilize smart contract to control transaction flows and manage access control policies automatically. Experimental results show that our proposed trust access authentication system enhances security, scales well, and is efficient and economically feasible.