Esitetään Jyväskylän yliopiston informaatioteknologian tiedekunnan suostumuksella julkisesti tarkastettavaksi yliopiston Agora-rakennuksen auditoriossa 3 joulukuun 12. päivänä 2014 kello 13.Academic dissertation to be publicly discussed, by permission of the Faculty of Information Technology of the University of Jyväskylä, in building Agora, auditorium 3, on December 12, 2014 at 13 o'clock. In this thesis, the solutions for efficiently offering two types of typical services (voice based RT services and data based NRT services) were investigated for evolution of a future network system. For the voice service characterized by the low latency and the small packet size, VoIP over E-DCH associated with DPCCH gating and/or packet bundling in uplink has been investigated and proven in a compelling performance. Moreover, HS-SCCH-less operation in the downlink and the enhanced packet scheduler have been studied to further improve the user end-to-end experience. The tradeoff between reduction of CQI reports and the reliability of the link adaption has also been evaluated for consideration in performance optimization. UNIVERSITYFor the data service, a hybrid network has been integrated using deviceto-device (D2D) communication into a LTE cellular network is envisioned and investigated as one potential solution. The various RRM schemes for mode selection, power control and resource allocation are studied, which are further complemented by a time hopping mechanism and the enhanced scheduler algorithm. Additionally, asymmetric D2D operation and semi-autonomous D2D were presented as different ways for D2D implementation. D2D based cluster operation was also studied for the potential of offering multicast services. The feedback mechanism for a multicast operation was discussed for assisting the cooperative D2D operation.In short, the VoIP based voice solutions and D2D based data solutions can be considered for future network evolution based on the studies in this thesis.
Corneal dystrophies are a clinically and genetically heterogeneous group of inherited disorders that bilaterally affect corneal transparency. They are defined according to the corneal layer affected and by their genetic cause. In this study, we identified a dominantly inherited epithelial recurrent erosion dystrophy (ERED)-like disease that is common in northern Sweden. Whole-exome sequencing resulted in the identification of a novel mutation, c.2816C>T, p.T939I, in the COL17A1 gene, which encodes collagen type XVII alpha 1. The variant segregated with disease in a genealogically expanded pedigree dating back 200 years. We also investigated a unique COL17A1 synonymous variant, c.3156C>T, identified in a previously reported unrelated dominant ERED-like family linked to a locus on chromosome 10q23-q24 encompassing COL17A1. We show that this variant introduces a cryptic donor site resulting in aberrant pre-mRNA splicing and is highly likely to be pathogenic. Bi-allelic COL17A1 mutations have previously been associated with a recessive skin disorder, junctional epidermolysis bullosa, with recurrent corneal erosions being reported in some cases. Our findings implicate presumed gain-of-function COL17A1 mutations causing dominantly inherited ERED and improve understanding of the underlying pathology.
The exponential growth of mobile data in macronetworks has driven the evolution of communications systems toward spectrally efficient, energy efficient, and fast local area communications. It is a well-known fact that the best way to increase capacity in a unit area is to introduce smaller cells. Local area communications are currently mainly driven by the IEEE 802.11 WLAN family being cheap and energy efficient with a low number of users per access point. For the future high user density scenarios, following the 802.11 HEW study group, the 802.11ax project has been initiated to improve the WLAN system performance. The 3GPP LTE-advanced (LTE-A) also includes new methods for pico and femto cell's interference management functionalities for small cell communications. The main problem with LTE-A is, however, that the physical layer numerology is still optimized for macrocells and not for local area communications. Furthermore, the overall complexity and the overheads of the control plane and reference symbols are too large for spectrally and energy efficient local area communications. In this paper, we provide first an overview of WLAN 802.11ac and LTE/LTE-A, discuss the pros and cons of both technology areas, and then derive a new flexible TDD-based radio interface parametrization for 5G local area communications combining the best practices of both WiFi and LTE-A technologies. We justify the system design based on local area propagation characteristics and expected traffic distributions and derive targets for future local area concepts. We concentrate on initial physical layer design and discuss how it maps to higher layer improvements. This paper shows that the new design can significantly reduce the latency of the system, and offer increased sleeping opportunities on both base station and user equipment sides leading to enhanced power savings. In addition, through careful design of the control overhead, we are able to improve the channel utilization when compared with LTE-A.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.