Whereas the heat transfer mechanisms in steady impinging jets are well understood, the available knowledge of heat transfer to impinging synthetic jets remains inconsistent. This paper provides an objective comparison of the stagnation point heat transfer performance of axisymmetric impinging synthetic jets versus established steady jet correlations. Furthermore, a general correlation for the stagnation point Nusselt number is proposed including the effect of all appropriate scaling parameters: Reynolds number (500 ≤ Re ≤ 1500), jet-to-surface spacing (2 ≤ H/D ≤ 16) and stroke length (2 ≤ /D ≤ 40). Based on the ratio of stroke length to jet-to-surface spacing L L 0 0 /H, four heat transfer regimes are identified.
Impinging synthetic jets have been identified as a promising technique for cooling miniature surfaces like electronic packages. This study investigates the relation between the convective heat transfer characteristics and the impinging synthetic jet flow structure, for a small jet-to-surface spacing H/D = 2, dimensionless stroke length 1 < L 0 /D < 22, and Reynolds number 1000 < Re < 4300. The heat transfer measurements show evidence for a power law relationship between the Reynolds and Nusselt number for a constant stroke length. A critical stroke length L 0 /H = 2.5 has been identified. Using phase-resolved particle image velocimetry, vortex quantification is applied to elucidate the influence of the impinging vortex on the timeaveraged heat transfer distribution.
-Impinging synthetic jets have excellent potential for energy-efficient local cooling in confined geometries. For a given geometry, synthetic jet flows are mainly characterised by the Reynolds number and the ratio of stroke length to a geometric length scale. The flow field of an impinging synthetic jet and the corresponding surface heat transfer distribution are strongly dependent on the dimensionless stroke length, yet few studies have investigated the flow field dependence for a wide range of stroke lengths. Therefore, the aim of this paper is to identify the various flow regimes as a function of stroke length. The experimental approach combines high speed particle image velocimetry and single point hot wire anemometry, and investigates an 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64
Purpose: The aim of this work was to evaluate the influence of crystal habit on the dissolution and in vitro antibacterial and anitiprotozoal activity of sulfadimidine:4-aminosalicylic acid cocrystals.Methods: Cocrystals were produced via milling or solvent mediated processes. In vitro dissolution was carried out in the flow-through apparatus, with shadowgraph imaging and mechanistic mathematical models used to observe and simulate particle dissolution. In vitro activity was tested using agar diffusion assays.Results: Cocrystallisation via milling produced small polyhedral crystals with antimicrobial activity significantly higher than sulfadimidine alone, consistent with a fast dissolution rate which was matched only by cocrystals which were milled following solvent evaporation.Cocrystallisation by solvent evaporation (ethanol, acetone) or spray drying produced flattened, plate-like or quasi-spherical cocrystals, respectively, with more hydrophobic surfaces and greater tendency to form aggregates in aqueous media, limiting both the dissolution rate and in vitro activity. Deviation from predicted dissolution profiles was attributable to aggregation behaviour, supported by observations from shadowgraph imaging.
Conclusions: Aggregation behaviour during dissolution of cocrystals with different habitsaffected the dissolution rate, consistent with in vitro activity. Combining mechanistic models with shadowgraph imaging is a valuable approach for dissolution process analysis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.