Background Ostomy barriers are adhesive devices designed to hold pouching systems to the abdomen and protect the peristomal skin from stoma effluent. The objective of this study was to determine differences in the extent of skin trauma resulting from serially applying and removing two types of ostomy barriers. Methods The study was a randomized, prospective, repeated measure trial involving healthy volunteers. The ostomy skin barriers were applied to the abdomen and changed every 3‐4 days over a 17‐day period. Skin observations (erythema, stripping, edge irritation and overall comparisons) were completed by a trained (blinded) observer. Transepidermal water loss (TEWL) measurements were completed by a separate (blinded) technician. TEWL was measured in a designated site and again in the most visually traumatized location at termination. Results Statistically significant differences were found between the two test devices in all assessments but visual observation of erythema. Highly significant differences in TEWL were found between the test products when measured at termination from the most visually traumatized sites. Conclusions The ostomy barrier with ceramide was significantly less disruptive to the epidermis than the ostomy barrier without ceramide. TEWL measurements were more sensitive to changes in the barrier function of the skin than visual observation of erythema.
OBJECTIVE: Sweating plays a critical role in maintaining thermal balance and keeping skin cool during exercise. People often wear sunscreens on hot summer days for sun protection. Most recreational sunscreens are designed to be water-and sweat-resistant, so that sweating will not remove or compromise the protection. The objective of this study was to determine whether wearing sweat-resistant sunscreen might impede natural sweating, potentially interfering with thermal regulation and resulting in the elevation of skin temperature. METHODS: We conducted a controlled, randomized, split-face and split-arm clinical study with 24 female subjects wearing an SPF 70 lotion sunscreen on half of the face and an SPF 70 spray sunscreen on one of the forearms at a dosage of 2 mg cm À2. Following sunscreen application, subjects participated in two sessions of indoor exercise to induce clearly visible sweating. RESULTS: We found that both skin temperatures and sweat evaporation rates were significantly elevated after each session, yet there were no significant differences in either skin temperatures or sweat rates between the treated and untreated control sites at any time point for any of the skin sites measured. CONCLUSION: We conclude that the application of tested sweatresistant sunscreen lotions and sprays does not have any measurable effects on skin cooling by natural sweating process. People should continue to use these sunscreens during recreational activities.R esum e OBJECTIF: La transpiration joue un rôle essentiel dans le maintien de l' equilibre thermique et pour garder la peau fraiche pendant l'exercice. Les gens portent souvent des ecrans solaires pendant les chaudes journ ees d' et e pour se prot eger du soleil. La plupart des ecrans solaires r ecr eatifs sont conc ßus pour r esister a l'eau et a la transpiration, de sorte que la transpiration n' elimine ni ne compromet la protection. L'objectif de cette etude etait de d eterminer si le port d'un ecran solaire r esistant a la transpiration pourrait entraver la transpiration naturelle, interf erant potentiellement avec la r egulation thermique et entraînant une el evation de la temp erature cutan ee. M ETHODES:Nous avons men e une etude clinique contrôl ee, randomis ee, h emi-visage et bras droit -bras gauche, avec 24 sujets f eminins portant un lotion solaire SPF 70 sur la moiti e du visage et un ecran solaire SPF 70 sur un des avant-bras a un dosage de 2 mg/cm2. Apr es l'application de la cr eme solaire, les sujets ont particip e a deux s eances d'exercices en salle pour induire une transpiration clairement visible. R ESULTATS: Nous avons constat e que les temp eratures cutan ees et les taux d' evaporation de la sueur etaient significativement elev es apr es chaque s eance, mais qu'il n'y avait pas de diff erences significatives de la temp erature cutan ee ou de la sudation entre les sites trait es et non trait es. CONCLUSION: Nous concluons que l'application de lotions antisolaires r esistants a la transpiration test es et des sprays n'a aucun effet m...
IntroductionIn plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0.05%) is a formulation composed of a topical steroid in an emollient-like vehicle that enhances penetration to the target site of inflammation in the skin. The aim of this study was to assess the effect of DFD-01 and its vehicle on skin hydration and barrier function in compromised skin and to evaluate its effect on flexibility in healthy skin.MethodsEighteen healthy white volunteers were enrolled in each of two studies. In Study 1, dry shaving of volar forearms created a compromised skin barrier, through which transepidermal water loss (TEWL) was measured using an evaporimeter. Capacitance, a measure of epidermal hydration, was also measured at baseline and at 1, 2 and 4 h after application of DFD-01 or its vehicle formulation. In Study 2, intact skin flexibility was tested with a cutometer before and at 1, 2 and 4 h after application of DFD-01 or vehicle.ResultsIn Study 1, both DFD-01 and its vehicle were effective at reducing TEWL through the compromised stratum corneum. Capacitance measurements confirmed this finding; razor-chafed skin treated with either DFD-01 or vehicle exhibited levels of skin hydration similar to unshaved control skin. Study 2 found softening and greater flexibility of normal skin treated with either DFD-01 or vehicle compared with nontreated control skin samples.ConclusionsThese tests suggest that the DFD-01 formulation and its vehicle are each effective at retaining moisture within a damaged skin barrier and for softening and increasing the flexibility of intact skin.FundingDr. Reddy’s Laboratories.
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