Objectives In 2013, the PharmaHelp device was introduced to daily patient care at the University Hospital of Heidelberg in order to improve process and staff safety and health. It is a semiautomated device located in a safety workbench for aseptic preparation with weight-and-visual-supported process check as well as radio-frequency identification of bags and vials. Methods After qualification and a training period, several high-admixture-volume drugs were chosen stepwise to be prepared by the device. During a reporting period of 6 months, the number of processed production runs and produced bags were assessed as well as the productivity per hour of the device based on the processed admixing volume and time consumption for manual preprocessing and postprocessing steps.
Background Oral anticancer drugs still contain some of the most critical issues in terms of right use and compliance. Patients need to be advised and guided concerning dosing schedules, risks and important supportive measures. Package sizes distributed by the pharmaceutical industry often contain more doses than one patient needs especially for short-term stays in the hospital. Purpose Our goal was to dispense patient-individual unit doses of oral anticancer drugs based on individual computerised prescriptions.
Materials and MethodsFor this purpose we implemented evidence-based treatment regimens in the prescription software to prevent errors and support the use of standardised treatment plans. Additionally patient information leaflets were created. The first drugs to be computerised in this way were capecitabine and temozolomide. Results Individualised dispensing of oral anticancer drugs allows more extensive pharmaceutical care of these patients. In view of the risks described above oral anticancer drugs have to undergo a pharmaceutical plausibility cheque and the amount has to be found suitable according to the treatment regime before dispensing. Moreover, the available instructions for use e.g. treatment schedules including supportive measures and the patient information brochure improve the information flow and the safe use. Conclusions Due to the positive feedback from the operators we are extending the procedure to all oral anticancer drugs.
No conflict of interest.InteractIons Between meDIcInal gases anD other meDIcInal proDucts: Development of a hospItal Drug DataBase
Als Off-Label-Use wird die Anwendung von Arzneimitteln außerhalb der in ihrerZulassung festgesetzten Rahmenbedingungen bezeichnet [1]. In Deutschland ist im Arzneimittelgesetz § 21 Abs. 1 und § 22 Abs. 1 geregelt, dass Fertigarzneimittel grundsätzlich nur in den Verkehr gebracht werden dürfen, wenn sie eine Zulassung besitzen. Um die Zulassung zu erhalten, muss die Qualität, Wirksamkeit und Unbedenklichkeit des Arzneimittels anhand von Daten aus klinischen Prüfungen nachgewiesen sein ( § § 22, 24 AMG). Durch dieses Verfahren wird die größtmögliche Sicherheit des Patienten angestrebt. Trotzdem kommt es insbesondere in den Bereichen der Pädiatrie, der Onkologie und bei der Behandlung seltener Erkrankungen vor, dass Arzneimittel außerhalb ihrer Zulassung angewendet werden (Off-Label-Use).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.