Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiological and pathological processes and contribute to the immune homeostasis in SLE. The effects of MSCs and EVs on SLE have been drawing more and more attention during the past few years. This article reviews the immunomodulatory effects and underlying mechanisms of MSC/MSC-EVs in SLE, which provides novel insight into understanding SLE pathogenesis and guiding the biological therapy.

This study investigated the moderating role of household registration in the relationship between housework division and second-child fertility anxiety among Chinese couples of childbearing ages. Multilevel cluster sampling was used to select 1834 respondents aged 20–45 years from Jilin Province in China between 2016 and 2017. A sample of 542 adults who were married and had only one child was included in the final analysis. Hierarchical multiple regression was used to examine the proposed hypothesis. The results showed that the association between housework division and second-child fertility anxiety was significant in rural areas. However, the above association was not significant in urban areas. Household registration status was found to have a moderating effect on the relationship between housework division and second-child fertility anxiety. Differences in gender and fertility ideology have led to different housework divisions in urban and rural areas, which in turn have led to different effects on the second-child fertility anxiety of couples of childbearing ages in these areas.

The present study explored the moderating effects of household income on the relationship between cognitive social capital and subjective well-being in rural community-dwelling older adults in China. The data were derived from a rural community survey conducted in Liaoyuan City in China’s Jilin Province in 2019. The analytic model featured 458 respondents who completed the survey. We used multiple group analyses to test the hypotheses. A latent construct of cognitive social capital was built using social trust and reciprocity indicators. The results showed that household income had a significant moderating effect on the association between cognitive social capital and life satisfaction, but not on the relationship between cognitive social capital and depressive symptoms. Thus, household income and cognitive social capital should be used to assess subjective well-being in older populations. Older adults with low household income deserve particular attention in the design of future social capital policies and programs.

The objective of the present study was to observe the curative effect and mechanism of melatonin for suppression of premature ovarian failure (POF). From December 2014 to June 2015, 128 patients were consecutively diagnosed with POF in the Department of Gynaecology and Obstetrics. The patients were randomly divided into the experimental and control groups. The experimental group received melatonin tablets (1–3 mg/day), while the control group received placebo tablets. The levels of six sex hormones, percentage of T lymphocytes in the G1/M phase, and levels of reactive oxygen species (ROS) were determined at four different time-points (1 day before treatment, and at 1, 3 and 6 months after treatment) in both groups. After 6 months of treatment, the levels of luteinizing hormone and follicle-stimulating hormone were significantly decreased in the experimental group compared with the control group (P<0.05). Compared with the control group, the levels of ROS in plasma were significantly decreased in the experimental group (P<0.05). Correlation analysis showed that the levels of melatonin in peripheral blood were negatively related with the levels of ROS (rs=−0.481, P<0.05). One-year follow-up study showed that the normal excretion of ovarian hormones in the experimental group was significantly higher than that of the control group (P<0.05). In conclusion, treatment with melatonin is an effective approach to suppress POF. The potential mechanism of melatonin is inhibition of ROS production and protection of the process of normal follicle development.

Emerging adults’ approaches to personal development in life may be revealed in their conception of wisdom resources (WRs), i.e., factors that lead to the development of wisdom. We explored the conception of WRs among 453 Chinese emerging and young adults aged 18–30. Participants completed an online questionnaire covering 19 potential WRs proposed by experts in the psychological study of wisdom and non-experts in Western and Chinese cultures. Participants indicated how much they agreed these factors lead to wisdom development. Afterward, they reported additional WRs not listed. The results revealed that “willingness to learn” was the most endorsed WR, while “religious/spiritual experience” was the least. Moreover, the conception of WRs varied significantly across different genders, ages, and education levels. Finally, although the conception of WRs among our participants was similar to that among Western laypeople, participants reported culturally unique WRs (e.g., motivation to pursue positive experiences, physical and psychological health). These findings may inspire future research on emerging adults’ wisdom development.