Introduction: Atopic dermatitis (AD) is an inflammatory skin disease with a chronic, relapsing course. Clinical features of AD vary by age, duration, and severity but can include papules, vesicles, erythema, exudate, xerosis, scaling, and lichenification. However, the most defining and universal symptom of AD is pruritus. Pruritus or itch, defined as an unpleasant urge to scratch, is problematic for many reasons, particularly its negative impact on quality of life. Despite the profoundly negative impact of pruritus on patients with AD, clinicians and researchers lack standardized and validated methods to objectively measure pruritus. The purpose of this review is to discuss emerging methods to assess pruritus in AD by describing objective patient-centered tools developed or enhanced over the last decade that can be utilized by clinicians and researchers alike. Methods: This review is based on a literature search in Medline, Embase, and Web of Science databases. The search was performed in February 2019. The keywords were
Introduction: Sleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption. Poor sleep among psoriasis patients is particularly concerning because psoriasis is independently associated with many of the same comorbidities as sleep dysfunction, including cardiovascular disease, obesity, and depression. Given the high Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.8208953.
Anamnese Ein zwei Tage altes neugeborenes Mädchen wurde in die dermatologische Klinik überwiesen wegen rasch aufgetretener livider Hautveränderungen. Das termingerecht geborene Kind war durch eine normale Vaginalgeburt mit einem Geburtsgewicht von 3,14 kg in einer Klinik der Maximalversorgung zur Welt gekommen und am folgenden Tag nach Hause entlassen worden. Am zweiten Lebenstag bemerkte die Mutter kleine schwarze Hautverfärbungen an Gesäß und Oberschenkeln, die im Laufe der Zeit immer größer wurden. An anderen Körperarealen traten ebenfalls neue Läsionen auf. Die Mutter stellte das Kind 18 Stunden später in der Kinderklinik vor. Das Mädchen wurde als Kind nicht konsanguiner Eltern geboren und hatte ein gesundes Geschwisterkind. Es gab keine Vorgeschichte für ähnliche Krankheiten oder postnatale Sterblichkeit in der Familie. Rasch progressive livid-schwarze Hautläsionen bei einem zwei Tage alten Neugeborenen Acute progressive purplish-black discolored skin lesions in a two-day-old newborn English online version on Wiley Online Library Diagnosequiz Abbildung 1 Mehrere große ekchymotische Plaques mit erythematösem Rand und zentraler Nekrose, die über Gesäß, Oberschenkel und Beine verteilt sind.
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