Summary
Fructan levels and mean molecular weights were measured throughout the year in leaves and stems of four forage grasses. In contrast to other studies, the major period of fructan synthesis in all varieties was autumn and winter, with maximal values in December. Extensive hydrolysis, accompanied by a decline in mean molecular weight, occurred between January and April. Fructan accumulation was maximal in periods when growth was restricted and the properties of the synthetic system are discussed in relation to the patterns of growth of temperate forage grasses.
The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001). This survival advantage for trial participants is most apparent among late Stage I patients, and is observed after matching for known prognostic factors (i.e., primary tumor size, nodal status, tumor histology) and after adjusting in the analysis for age, sex, and the administration of radiation therapy. Several explanations for the improved outcome for trial patients are explored, including differences in preoperative evaluation, staging, surgical technique, placebo effects, and patient motivation. These results suggest the possibility that inclusion in these controlled cancer trials may have had an inherent advantage for all participants.
Herbicides have been postulated as a cause of the disappearance of submerged aquatic vegetation in the Chesapeake Bay. This research was undertaken to determine the longevity of 2‐chloro‐4‐ethylamino‐6‐isopropylamino‐s‐triazine (atrazine) in two estuarine water/sediment microcosm systems and two agricultural soil systems over an 80‐d period under aerobic and low‐O2 conditions. Atrazine degradation proceeded more rapidly in the estuarine systems than in the soil systems. The disappearance of atrazine from the estuarine water was relatively rapid, with the half‐life (50% remaining in the water column) of the parent compound ranging from 3 to 12 d. Atrazine half‐life was determined to be 15 and 20 d for the two estuarine sediments and 330 and 385 d for the two agricultural soils. Hydroxyatrazine (2‐hydroxy‐4‐ethylamino‐6‐isopropylamino‐s‐triazine) was the major short‐term metabolite in both the estuarine and terrestrial systems. By the 21st day of the experiment, the percent of total extracted residues corresponding to atrazine and hydroxyatrazine were: 65, 20 and 10, 85 for the two estuarine systems; and 66, 29 and 93, 5 for the two soil systems. Decreased O2 levels had little effect on atrazine degradation in the experimental systems. The rapid degradation of atrazine to hydroxyatrazine in estuarine water and sediment indicates a low probability for the accumulation of atrazine in the estuary.
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