Sudden cardiac events are responsible for 40-50% of line-of-duty firefighter fatalities, yet the exact cause of these events is unknown. Likely, combinations of thermal, physical, and mental factors impair cardiovascular function and trigger such events. Therefore, the purpose of this study was to examine the impact of firefighting activities on vascular function. Sixty-nine young (28 ± 1 years) male firefighters underwent 3 hours of firefighting activities. Carotid, aortic, and brachial blood pressures (BP), heart rate (HR), augmentation index (AIx), wave reflection timing (TR), aortic pulse wave velocity (PWV), forearm blood flow (FBF), and forearm reactive hyperemia (RH) were measured before and after firefighting activities. Paired samples t-tests revealed significant (p < 0.05) increases in aortic diastolic BP, HR, AIx, PWV, RH, and FBF, and significant decreases in brachial and aortic pulse pressure and TR following firefighting activities. In conclusion, these results suggest that 3 hours of firefighting activities increase both arterial stiffness and vasodilation.

Previous investigations have indicated that children demonstrate a lower cardiac output at a given oxygen uptake during exercise compared with adults. This study compared cardiac responses with maximal upright cycle exercise in 15 boys (mean age 10.9 yr) and 16 men (mean age 30.7 yr) to determine whether this observation reflects differences in size or age-related influences on myocardial function. Stroke volume, aortic peak velocity, and systolic ejection time were measured to peak exercise in all subjects using Doppler ultrasound techniques. No significant differences were observed in resting, submaximal, or peak mean values for these variables relative to body size between the boys and men. Average values for peak stroke index, cardiac index, and peak aortic velocity were 59 (+/-11) mL.m-2, 11.33 (+/-2.32) L.min-1.m-2, and 152 (+/-30) cm.s-1, respectively, for the boys. Respective values for the men were 61 (+/-14) mL.m-2, 11.08 (+/-2.52) L.min-1.m-2, and 144 (+/-24) cm.s-1 (P > 0.05). This study failed to demonstrate evidence of impaired cardiac responses to maximal exercise in prepubertal boys compared with that in adult males.

Adjustment of VO2max for changes in body size is important in evaluating aerobic fitness in children. It is important, therefore, to understand the normal relationship between changes VO2max and body size during growth. Over the course of 5 years, 20 children (11 boys, 9 girls) underwent annual maximal treadmill testing to determine VO2max. The mean longitudinal allometric scaling exponent for VO2max relative to body mass (M) was 1.10 ± 0.30 in the boys and 0.78 ± 0.28 in the girls (p < .05). Respective cross-sectional values were 0.53 ± 0.08 and 0.65 ± 0.03. VO2max expressed relative to M1.0, M0.75, and M0.67 rose during the 5 years in the boys, but not the girls. Significant gender differences remained when VO2max was related to lean body mass. These findings suggest (a) factors other than body size affect the development of VO2max in children, and (b) gender differences exist in VO2max during childhood which are independent of body composition.

It is well established that exercise elicits a finely tuned adaptive response in skeletal muscle, with contraction frequency, duration, and recovery shaping skeletal muscle plasticity. Given the power of physical activity to regulate metabolic health, numerous research groups have focused on the molecular mechanisms that sense, interpret, and translate this contractile signal into postexercise adaptation. While our current understanding is that contraction-sensitive allosteric factors (e.g., Ca2+, AMP, NAD+, and acetyl-CoA) initiate signaling changes, how the muscle translates changes in these factors into the appropriate adaptive response remains poorly understood. During the past decade, systems biology approaches, utilizing “omics” screening techniques, have allowed researchers to define global processes of regulation with incredible sensitivity and specificity. As a result, physiologists are now able to study substrate flux with stable isotope tracers in combination with metabolomic approaches and to coordinate these functional changes with proteomic and transcriptomic analysis. In this review, we highlight lysine acetylation as an important posttranslational modification in skeletal muscle. We discuss the evolution of acetylation research and detail how large proteomic screens in diverse metabolic systems have led to the current hypothesis that acetylation may be a fundamental mechanism to fine-tune metabolic adaptation in skeletal muscle.

Prior experience of fatiguing tasks is considered essential to establishing an optimal pacing strategy. This study examined the pacing behavior of inexperienced children during self-paced, 800 m running, both individually and within a competitive environment. Thirteen children (aged 9−11 y) completed a graded-exercise test to volitional exhaustion on a treadmill (laboratory trial), followed by three self-paced, individual 800 m time-trials (Trials 1−3) and one self-paced, competitive 800 m time-trial (Trial 4) on an outdoor athletics track. Ratings of perceived exertion (RPE) and heart rate (HR) were measured throughout all trials. Overall performance time improved from Trial 1−3 (250.1 ± 50.4 s & 242.4 ± 51.5 s, respectively, p < .017). The difference in overall performance time between Trials 3 and 4 (260.5 ± 54.2 s) was approaching significance (p = .06). The pacing strategy employed from the outset was consistent across all trials. These findings dispute the notion that an optimal pacing strategy is learned with exercise experience or training.

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Untrained subjects typically demonstrate a plateau in stroke volume beyond the early stages of an acute bout of progressive exercise. Some studies have indicated that the stroke volume pattern in highly trained endurance athletes may differ, continuing to rise progressively to the point of maximal exercise. This suggests that the mechanism for generating cardiac output in these athletes may be influenced by cardiac functional factors, particularly augmented diastolic filling. This review of studies assessing stroke volume changes with exercise in athletes reveals a wide disparity of reported patterns, ranging from those indicating a decline, to stable values (a true plateau), to a progressive increase to exhaustion of over 40%. Differences in testing methodology might help to explain these variable results, but which pattern truly reflects that expected in highly trained endurance athletes remains uncertain. Ancillary data suggest that if a non-plateau of stroke volume is typical of athletes, augmented diastolic filling might be the responsible mechanism. However, it is not clear whether this might reflect superior upstream (atrial pressure/volume) or downstream (ventricular diastolic function, compliance) factors.

There is still considerable debate and some confusion as to the most appropriate method of scaling or normalizing maximum oxygen uptake ( _ V O 2max ) for differences in body mass (m) in both adults and children. Previous studies on adult populations have demonstrated that although the traditional ratio standard _ V O 2max (ml kg )1 min )1 ) fails to render _ V O 2max independent of body mass, the ratio standard is still the best predictor of running performance. However, no such evidence exists in children. Hence, the purpose of the present study was to investigate whether the ratio standard is still the most appropriate method of normalising _ V O 2max to predict 1-mile run speed in a group of 12-year-old children (n=36). Using a power function model and log-linear regression, the best predictor of 1-mile run speed was given by: speed (m s . With both the _ V O 2max and body mass exponents being close to unity but with opposite signs, the model suggest the best predictor of 1-mile run speed is almost exactly the traditional ratio standard recorded in the units (ml kg )1 min )1 ). Clearly, reporting the traditional ratio standard _ V O 2max , recorded in the units (ml kg )1 min )1), still has an important place in publishing the results of studies investigating cardiovascular fitness of both children and adults.