The integration of social science with computer science and engineering fields has produced a new area of study: computational social science. This field applies computational methods to novel sources of digital data such as social media, administrative records, and historical archives to develop theories of human behavior. We review the evolution of this field within sociology via bibliometric analysis and in-depth analysis of the following subfields where this new work is appearing most rapidly: ( a) social network analysis and group formation; ( b) collective behavior and political sociology; ( c) the sociology of knowledge; ( d) cultural sociology, social psychology, and emotions; ( e) the production of culture; (  f ) economic sociology and organizations; and ( g) demography and population studies. Our review reveals that sociologists are not only at the center of cutting-edge research that addresses longstanding questions about human behavior but also developing new lines of inquiry about digital spaces as well. We conclude by discussing challenging new obstacles in the field, calling for increased attention to sociological theory, and identifying new areas where computational social science might be further integrated into mainstream sociology. Expected final online publication date for the Annual Review of Sociology, Volume 46 is July 30, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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ObjectiveBisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is triggered by inflammatory processes. Typical trigger factors are periodontal disease, denture pressure sores, and surgical interventions such as tooth extractions. Unfortunately there is only little data on how to proceed with implant therapy in patients with bisphosphonate treatment. This topic is not addressed in the German guidelines on medication-associated osteonecrosis. Therefore a systematic literature review was performed.MethodsThe PICO design was used: (Patients) For which subclientel of patients with antiresorptive therapy (intervention) do dental implants have a benefit (control) compared to forgoing dental implants (outcome) in regards to oral rehabilitation and quality of life without having a substantial risk of BP-ONJ development? A PubMed search was performed including all studies dealing with this topic. Case reports and studies with less than 5 cases were excluded.ResultsThere is only very little data available, mostly retrospective case series. 50 articles were analyzed in detail. BP-ONJ can be triggered by dental implants and by dentures in patients with benign and malignant primary diseases. In most studies, analyzing osteoporosis patients only, no cases of BP-ONJ were observed in patients with implant therapy in the time span observed. There are no studies about implant therapy in patients with malignant diseases. Many case series analyzing the trigger factors for BP-ONJ describe dentures as one of the main causes. Perioperative antimicrobial prophylaxis has a benefit in the prevention of BP-ONJ development.ConclusionSuccessful implant therapy is possible in patients receiving antiresorptive therapy. The possibility of osteonecrosis development needs to be explained to the patient. An individual risk assessment is essential, taking the primary disease with the medication and further wound-healing-compromising diseases and medications into account. If possible, bone augmentations should be avoided, and a perioperative antimicrobiological prophylaxis is strongly recommended in these patients.

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