Pain and tenderness of masticatory muscles are often related to muscle tenderness elsewhere in the body. It has been shown that women are more prone to musculoskeletal disorders than men. We sought to determine whether sex differences of muscular symptoms were established by the age of 19. The subjects comprised 51 boys and girls who received a questionnaire regarding the function of their masticatory system, frequency of headache, and neck, shoulder and low back pain. Their masticatory system was examined, and neck and shoulders were palpated. For all variables in the questionnaire girls reported symptoms more often than the boys. Of the subjects 50% had tender chewing muscles upon palpation. Again the girls had the most. There was good correlation between reports of pain in one area as compared to others. The number of clinically tender neck and shoulder muscles correlated with the number of tender masticatory muscles. It was concluded that girls presented more muscular symptoms than boys.

Fifty-one individuals (28 girls and 23 boys) who had received orthodontic treatment were compared as to signs and symptoms of craniomandibular disorders with 47 individuals (19 girls and 28 boys) without such treatment. All were 19 years old. An average of 5 years had elapsed since the termination of the treatment. The examinations enabled calculations of the anamnestic, the clinical dysfunction, and the occlusal indices of Helkimo. There were no statistically significant differences between the groups except with regard to the anamnestic index. Subjects who had not received orthodontic treatment reported most symptoms, but none were severe. In conclusion, there were no substantial differences as to signs and symptoms of craniomandibular disorders in these two groups of individuals.

Fifty-one individuals (28 girls and 23 boys) who had received orthodontic treatment were compared with 47 subjects (19 girls and 28 boys) without such treatment as to maximal mandibular mobility, chewing muscle tenderness, morphologic occlusion, occlusal/incisal state, and degree of tooth wear. All were 19 years old. There were no statistically significant differences between the groups except for the number of teeth present and maximal mouth opening, which were both smallest in those who had received treatment. The first finding is evident, extraction of premolars being an accepted mode of orthodontic treatment. The reduced mouth opening capacity was related to an increased number of individuals with four or more palpably tender muscle sites in that group of individuals.

The aim of this investigation was to study intra-assessor reliability and the relationship between individual and simultaneous evaluations when retention and stability of complete prostheses and the condition of the residual ridges were clinically assessed according to defined criteria. Further, inter-assessor reliability and the reliability of simultaneous evaluations were studied by evaluating the condition of the residual ridge on two occasions. Nine patients and three prosthodontists participated. Generally, the reliability levels were low and individual deviations from the simultaneous evaluations were common.

The effect of cyclophosphamide on the healing of open cutaneous wounds was studied in rats. Following intraperitoneal injections of 25 mg/kg body weight every second day for 9 days, only about 7% of the wounds were completely covered by epithelium after 15 days, whereas in the control animals 60% of the wounds were completely epithelialized. Measurements of wound diameters in circular skin wounds revealed unhealed wound areas in the drugtreated animals which were significantly larger than those of the control animals. Cyclophosphamide was found to reduce the occurrence of H3‐labelled cells in the granulation tissue when evaluated after 11 days. At 15 days there was no difference in the labelling frequency between treated and control animals, indicating reversal of the drug effect.