The exact connection between Alzheimer’s disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer’s. This relationship is so strong that some have called Alzheimer’s “diabetes of the brain” or “type 3 diabetes (T3D)”. Given more recent studies continue to indicate evidence linking T3D with AD, this review aims to demonstrate the relationship between T3D and AD based on the fact that both the processing of amyloid-β (Aβ) precursor protein toxicity and the clearance of Aβ are attributed to impaired insulin signaling, and that insulin resistance mediates the dysregulation of bioenergetics and progress to AD. Furthermore, insulin-related therapeutic strategies are suggested to succeed in the development of therapies for AD by slowing down their progressive nature or even halting their future complications.
The remedies used for the COVID-19 pandemic such as travel restrictions and quarantine have created severe difficulties for the hotel industry. However, there is also a scarcity of effective response strategies for the tourism and hospitality industry. This paper introduces a responding strategy developed by a case hotel in Vietnam to help survive this troubled period. Marketing's service-dominant logic and Bourdieu's theoretical framework of habitus, capitals, and field are used to facilitate the analysis of findings. Our empirical analysis further highlights the development of the paid quarantine service in a case hotel, which can help both hotels and authorities in Vietnam to respond effectively to the pandemic.
In multi-area interconnected power systems (MAIPS), the measurement of all system states is difficult due to the lack of a sensor or the fact that it is expensive to measure. In order to solve this limitation, a new load frequency controller based on the second-order sliding mode is designed for MAIPS where the estimated state variable is used fully in the sliding surface and controller. Firstly, a model of MAIPS integrated with disturbance is introduced. Secondly, an observer has been designed and used to estimate the unmeasured variables with disturbance. Thirdly, a new second-order sliding mode control (SOSMC) law is used to reduce the chattering in the system dynamics where slide surface and sliding mode controller are designed based on system states observer. The stability of the whole system is guaranteed via the Lyapunov theory. Even though state variables are not measured, the experimental simulation results show that the frequency remains in the nominal range under load disturbances, matched and mismatched uncertainties of the MAIPS. A comparison to other controllers illustrates the superiority of the highlighted controller designed in this paper.
A number of studies have indicated that short food supply chains could create economic, social, and environmental benefits, but most of those chains were implemented in developed countries. This research aims to find out the characteristics of short food supply chains and their benefits to small farmers in Vietnam, which is a developing country, based on the survey results from 338 small farmers in the third quarter of 2020, with the support of Stata 14 software. The results showed that the short food supply chains in the survey sample in Vietnam were characterized by two main actors: small farmers and distributors. Farmers could sell products flexibly at the local market. There was some initial evidence to prove that these chains helped to stabilize the input, output price, and revenue; formulated sustainable income; and increased the satisfaction and confidence of farmers. They eliminated gender discrimination in rural areas and improved livelihood for ethnic minorities. These chains also enhanced the mindset on green, organic, and clean production of farmers, which in turn created environmental benefits. COVID-19 has posed a negative impact on the income of farmers and made them change their production and sales method. Therefore, the research could suggest some policies to sustainably develop the short food supply chains in Vietnam in the future.
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