Ultrafine bubbles stabilized by human serum albumin conjugate polyethylene glycol ameliorates the stability of complex as well as the drug payload. Polyethylene glycol presents the crucial role in releasing drug by means of acoustic sound.
The
cause of the Jones–Ray effect has been controversially
debated for years. Ultrafine gas bubbles were employed to lessen the
surface excess of the surface-active impurities adsorbing to the air/water
interface of the salt solutions, which would lead to a direct shift
in surface tension observable by the Wilhelmy plate method. It was
concluded in this study that once the surface excess of the inevitable
impurities in the salts is lessened by the introduction of ultrafine
gas bubbles, which possess great air/water interfacial area, the Jones–Ray
effect becomes nonobservable. Therefore, our finding hypothesized
that the Jones–Ray effect might not originate from salts.
As the SDS concentration increases in bubble rich solutions, the surfactant layer alters its size and refractive index. The scattered light enhancement and SFG signal cancellation prove that sub-monolayer adsorption exists at the air/water interface.
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