Utilizing polymer-conjugate albumin-based ultrafine gas bubbles in combination with ultra-high frequency radiations in drug transportation and delivery

Le, Thi H.; Phan, An H. T.; Le, Khoa C. M.; Phan, Thy D. U.; Nguyen, Khoi Tan

doi:10.1039/d1ra04983f

Cited by 6 publications

(4 citation statements)

References 77 publications

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“…It is worth noting that the burst of gas bubbles during high-frequency ultrasound exposure leads to physical damage on the vascular wall, as illustrated in Figure c. The control experiment, however, showed that certain acoustic radiation did not result in significant bubble bursting, enabling the plausibility of using UBs to transport and deliver drugs …”

Section: Results and Discussionmentioning

confidence: 99%

“…The control experiment, however, showed that certain acoustic radiation did not result in significant bubble bursting, enabling the plausibility of using UBs to transport and deliver drugs. 86 Unfortunately, the number of cells that are harmed by one single bubble burst as well as the amount of surrounding liquid subjected to such a high energy remains unknown. In a study by Walls et al on the estimation of the risk that bursting bubbles of various sizes can cause suspended cells, it was indicated that at a constant flow rate, larger relative volumes are damaged by smaller bubbles.…”

Section: Interaction Between Ultrafine Bubbles and Mammalian Cells Di...mentioning

confidence: 99%

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Review on the Significant Interactions between Ultrafine Gas Bubbles and Biological Systems

Tran,

Lam,

Duong

et al. 2023

Langmuir

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Having sizes comparable with living cells and high abundance, ultrafine bubbles (UBs) are prone to inevitable interactions with different types of cells and facilitate alterations in physiological properties. The interactions of four typical cell types (e.g., bacterial, fungal, plant, and mammalian cells) with UBs have been studied over recent years. For bacterial cells, UBs have been utilized in creating the capillary force to tear down biofilms. The release of high amounts of heat, pressure, and free radicals during bubble rupture is also found to affect bacterial cell growth. Similarly, the bubble gas core identity plays an important role in the development of fungal cells. By the proposed mechanism of attachment of UBs on hydrophobin proteins in the fungal cell wall, oxygen and ozone gas-filled ultrafine bubbles can either promote or hinder the cell growth rate. On the other hand, reactive oxygen species (ROS) formation and mass transfer facilitation are two means of indirect interactions between UBs and plant cells. Likewise, the use of different gas cores in generating bubbles can produce different physical effects on these cells, for example, hydrogen gas for antioxidation against infections and oxygen for oxidation of toxic metal ions. For mammalian cells, the importance of investigating their interactions with UBs lies in the bubbles’ action on cell viability as membrane poration for drug delivery can greatly affect cells’ survival. UBs have been utilized and tested in forming the pores by different methods, ranging from bubble oscillation and microstream generation through acoustic cavitation to bubble implosion.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Interaction Between Ultrafine Bubbles and Mammalian Cells Di...mentioning

confidence: 99%

Review on the Significant Interactions between Ultrafine Gas Bubbles and Biological Systems

Tran,

Lam,

Duong

et al. 2023

Langmuir

Self Cite

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“…One of the characteristics of the bubble reagents used in medical applications and research is that they are stabilized by shells composed of various compounds. MB and NB shells can be composed of phospholipids [ 44 , 45 ], polymers [ 46 , 47 ], or proteins such as HSA [ 48 , 49 , 50 , 51 ]. HSA, which consists of three flexible spheres (domains I, II, and III) and two binding sites that provide pockets for small molecules, mainly aromatic dyes (binding site 1) and lipophilic carboxylic acid derivatives (binding site 2) [ 52 , 53 ], is an abundant protein in the human body and is thus highly biocompatible.…”

Section: Discussionmentioning

confidence: 99%

“…Albumin-shell bubbles can also carry pDNA [ 62 , 63 ] and viruses containing integrated genes [ 64 ]. Furthermore, HSA-based bubbles can be PEGylated to improve stability [ 50 ]. In our previous study, we developed albumin-based NBs and investigated their characteristics.…”

Section: Discussionmentioning

confidence: 99%

Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles

et al. 2023

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In this study, we developed an efficient mRNA delivery vehicle by optimizing a lyophilization method for preserving human serum albumin-based nanobubbles (HSA-NBs), bypassing the need for artificial stabilizers. The morphology of the lyophilized material was verified using scanning electron microscopy, and the concentration, size, and mass of regenerated HSA-NBs were verified using flow cytometry, nanoparticle tracking analysis, and resonance mass measurements, and compared to those before lyophilization. The study also evaluated the response of HSA-NBs to 1 MHz ultrasound irradiation and their ultrasound (US) contrast effect. The functionality of the regenerated HSA-NBs was confirmed by an increased expression of intracellularly transferred Gluc mRNA, with increasing intensity of US irradiation. The results indicated that HSA-NBs retained their structural and functional integrity markedly, post-lyophilization. These findings support the potential of lyophilized HSA-NBs, as efficient imaging, and drug delivery systems for various medical applications.

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Laser Controlled Manipulation of Microbubbles on a Surface with Silica‐Coated Gold Nanoparticle Array

Wang

Xia

et al. 2023

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Microbubble generation and manipulation play critical roles in diverse applications such as microfluidic mixing, pumping, and microrobot propulsion. However, existing methods are typically limited to lateral movements on customized substrates or rely on specific liquids with particular properties or designed concentration gradients, thereby hindering their practical applications. To address this challenge, this paper presents a method that enables robust vertical manipulation of microbubbles. By focusing a resonant laser on hydrophilic silica‐coated gold nanoparticle arrays immersed in water, plasmonic microbubbles are generated and detach from the substrates immediately upon cessation of laser irradiation. Using simple laser pulse control, it can achieve an adjustable size and frequency of bubble bouncing, which is governed by the movement of the three‐phase contact line during surface wetting. Furthermore, it demonstrates that rising bubbles can be pulled back by laser irradiation induced thermal Marangoni flow, which is verified by particle image velocimetry measurements and numerical simulations. This study provides novel insights into flexible bubble manipulation and integration in microfluidics, with significant implications for various applications including mixing, drug delivery, and the development of soft actuators.

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Utilizing polymer-conjugate albumin-based ultrafine gas bubbles in combination with ultra-high frequency radiations in drug transportation and delivery

Abstract: Ultrafine bubbles stabilized by human serum albumin conjugate polyethylene glycol ameliorates the stability of complex as well as the drug payload. Polyethylene glycol presents the crucial role in releasing drug by means of acoustic sound.

Cited by 6 publications

References 77 publications

Review on the Significant Interactions between Ultrafine Gas Bubbles and Biological Systems

Review on the Significant Interactions between Ultrafine Gas Bubbles and Biological Systems

Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles

Laser Controlled Manipulation of Microbubbles on a Surface with Silica‐Coated Gold Nanoparticle Array

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