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BackgroundIncreased prevalence of depression has been observed among patients with multiple sclerosis (MS) and correlated with the elevated levels of proinflammatory cytokines and the overall deregulation of monoaminergic neurotransmitters that these patients exhibit. Antidepressants have proved effective not only in treating depression comorbid to MS, but also in alleviating numerous MS symptoms and even minimizing stress-related relapses. Therefore, these agents could prospectively prove beneficial as a complementary MS therapy.ObjectiveThis review aims at illustrating the underlying mechanisms involved in the beneficial clinical effects of antidepressants observed in MS patients.MethodsThrough a literature search we screened and comparatively assessed papers on the effects of antidepressant use both in vitro and in vivo MS models, taking into account a number of inclusion and exclusion criteria.ResultsIn vitro studies indicated that antidepressants promote neural and glial cell viability and differentiation, reduce proinflammatory cytokines and exert neuroprotective activity by eliminating axonal loss. In vivo studies confirmed that antidepressants delayed disease onset and alleviated symptoms in Experimental Autoimmune Encephalomyelitis (EAE), the most prevalent animal model of MS. Further, antidepressant agents suppressed inflammation and restrained demyelination by decreasing immune cell infiltration of the CNS.ConclusionAntidepressants were efficient in tackling numerous aspects of disease pathophysiology both in vitro and in vivo models. Given that several antidepressants have already proved effective in clinical trials on MS patients, the inclusion of such agents in the therapeutic arsenal of MS should be seriously considered, following an individualized approach to minimize the adverse events of antidepressants in MS patients.

During the total solar eclipse at Akademgorodok, Siberia, Russia, on 1 August 2008, we imaged the flash spectrum with a slitless spectrograph. We have spectroscopically determined the duration of totality, the epoch of the second and third contacts and the duration of the flash spectrum. Here we compare the 2008 flash spectra with those that we similarly obtained from the total solar eclipse of 29 March 2006, at Kastellorizo, Greece. Any changes of the intensity of the coronal emission lines, in particularly those of Fe X and Fe XIV, could give us valuable information about the temperature of the corona. The results show that the ionization state of the corona, as manifested especially by the Fe XIV emission line, was much weaker during the 2008 eclipse, indicating that following the long, inactive period during the solar minimum, there was a drop in the overall temperature of the solar corona.

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