Mass spectra of impurities and artifacts of illicit cocaine are illustrated and discussed. The methods used in the synthesis of the compounds are described and nuclear magnetic resonance data are presented as proof of structure.
Tetrachloroethylene was indicated in the accidental death of a man clearing a line in a dry-cleaning establishment. Blood and tissue concentrations were measured by gas chromatography-mass fragmentography. Distribution of tetrachloroethylene was consistent with its lipophilic properties, being highest in the brain and lowest in the lung tissue.
An injection port pyrolysis method for the analysis of quaternary ammonium compounds is reported. Identification and confirmation of the analyte was accomplished by gas chromatography/mass spectrometry. With minor modifications to pH used and solvent composition, a common ion-pair method of extraction of quaternary ammonium compounds from biological matrices with an iodide counter ion is described. Although the combined extraction-identification methodology was limited to neostigmine, succinylcholine, and paraquat, it should easily be applicable to any of the other compounds examined in this study.
The ultraviolet, infrared, nuclear magnetic resonance, and mass spectra of a number of precursors, intermediates, and impurities of 3,4-methylenedioxyamphetamine (MDA) synthesis are presented as well as gas-liquid and thin layer chromatographic data. Test results are given on the precursors safrole, isosafrole, and piperonal; the intermediates isosafrole glycol, N-formyl-MDA, and l-(3,4-methylenedioxyphenyl)- 2-nitro-l-propene; the impurities di[l- (3,4-methylenedioxyphenyl) -2-propyl] amine, di[l - (3,4 - methylenedioxyphenyl) -2- propyl] methylamine, and 3,4-methylenedioxyphenyIpropane; and the product MDA. The data are discussed and 2 methods of MDA synthesis are summarized, in which the precursors, intermediates, and impurities are encountered.
MDA was indicated in the death of a 35-year-old male. Blood, tissue, and urine concentrations of MDA were measured by ultraviolet spectrophotometry after identification by gas chromatography/mass spectrometry. The concentrations found were within the range of previously reported fatal MDA levels.
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