Ouratea species are used for the treatment of inflammation-related diseases such as rheumatism and arthritic disorders. The Ouratea genus is a rich source of flavonoids and bioflavonoids and for this reason we evaluated the effects of the biflavonoid fractions from the leaves of O. hexasperma (OHME) and O. ferruginea (OFME) in the in vivo model of complete Freund’s adjuvant (CFA)-induced arthritis and in the in vitro model of oxidative stress and cellular viability. The CFA-induced arthritis model in rats was followed by paw volume, articular incapacitation and Randall-selitto models, as well as quantification of cytokines and serum C-terminal telopeptide of type I collagen levels. OHME and OFME demonstrated antinociceptive and anti-inflammatory activities, as well as improvement in articular incapacity and reduction in levels of interleukin 1β (IL-1β), IL-6, tumor necrosis factor α, and type 1 collagen, and increased cell viability. No adverse effects were observed. The results suggest that OHME and OFME can reduce inflammation and bone resorption besides their antioxidant action.
Background and objectivesUltra-processed food products (UPF) have been associated with numerous non-communicable diseases. Despite this, the addictive nature of UPF, and the aggressive marketing strategies used to promote them, has created a strong emotional connection between UPF and consumers, and supports their increasing UPF global consumption. In view of the emotional link that consumers often have with UPF, modulating emotional reactions to UPF (by using strategies such as textual warnings) is important in changing consumers’ behavior. Since emotions are better understood by assessing individuals’ implicit reactions, we conducted an electroencephalographic study applying the event-related potential technique to investigate whether textual warnings were able to modulate the brain responses to UPF stimuli.Materials and methodsTwenty-six participants (19 women) viewed pictures of UPF preceded by a warning sentence about the health risks of consuming UPF or a control sentence while the electroencephalogram was recorded. In addition, the participants rated the picture in respect of pleasantness, arousal, and intention to consume. As emotions are associated with motivational circuits in the brain, we focused on a well-known event-related potential brain marker of the motivational relevance associated with emotional stimuli, namely late positive potential (LPP).ResultsThe late positive potential amplitude was larger for pictures depicting UPF under the warning condition compared to the control condition, a result that was accompanied by lower pleasantness ratings during the warning condition (compared to the control).ConclusionTextual warnings about the negative health consequences of consuming UPF changed the emotional responses toward UPF, possibly increasing the motivation to avoid UPF. These results shed new light on the impact of textual warnings on UPF-evoked emotions.
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