Topical and systemic use of Joannesia princeps vell. LC seed oil in acute pain and inflammation induced by different agents

Souza, Milene Conceição de; Hubner, Jhones Trindade; Gonçalves, Gabriela Mastrangelo; Fernandes, Thayane Ferreira; Laureano‐Melo, Roberto; Cortês, Wellington da Silva; Gonçalves, Letícia; Silva, Francisco de Assis da; Marinho, Bruno Guimarães

doi:10.1016/j.jep.2020.113554

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…New investigation into the existence of possible mutagenic effects using Allium cepa and tests with micronuclei also demonstrated no harmful effects [18]; iv. In more recent studies, it was demonstrated that: Joannesia princeps seed oil has antinociceptive and antiinflammatory action through its topical and systemic administration, promoted by the inhibition of leukocyte recruitment and cytokine production [19]. In this work we define that this oil contained in the seed of Joannesia princeps, obtained by soxhlet extraction using hexane as solvent, is composed of a triglyceride mainly present, in addition to showing that simple reactions suggest products originating from interesting thermal rearrangements.…”

Section: Introductionmentioning

confidence: 69%

Confirmation, Through Structural Modifications, of Tri-Acyl-Glyceride (TAG) Obtained by Extraction from the Seed of Joanesia princeps (Cutieira a Euphorbiaceae)

Oliveira,

Berty,

Hubner

et al. 2024

JER

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In the present work, we report the characterization, after isolation, of a triglyceride (TAG) from seeds of Joannesia princeps vell, a Euphorbiaceae, through extraction in a soxhlet apparatus, using hexane as an extracting solvent. The proposed structure of TAG was determined by spectrometric analyses: high-resolution GC/MS; I.V.; R.M.N. 1H and 13C. Spectra of RMN ( 1 H; 13 C; H x H COSY e DEPT-45) indicate that all signals observed in the spectra belong to a single compound, a TAG containing two identical units and one different. A structure is proposed that, through hydrolysis in methanol/sodium methoxide, leads to two units of methyl linoleate ester and one of methyl oleate ester. Therefore, a molecular weight of 880g.mol-1 and formula C57H100O6 can be proposed. Confirmation of the structure is also done by comparing the proposed structure with another TAG described in the literature. Reaction of the mixture produced by basic hydrolysis with dimethyl-disulfide (CH3-S-S-CH3) confirms the positions of the unsaturations of the oleic and linoleic units; in addition to demonstrating the obtaining of a product originating from a thermal mechanism, under mass spectroscopy analysis. Therefore, in general, this TAG with a mild and slightly yellowish aroma is a mix of omega-9 and omega-6; which corresponds to approximately 40% of the seed mass, in addition to being probably one of the main responsible for physiological activities described in the literature. Another predominant TAG with a molecular mass of 878g.mol -1 , was detected by high-resolution mass spectroscopy, after a period of seed storage in a desiccator.

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Section: Introductionmentioning

confidence: 69%

Confirmation, Through Structural Modifications, of Tri-Acyl-Glyceride (TAG) Obtained by Extraction from the Seed of Joanesia princeps (Cutieira a Euphorbiaceae)

Oliveira,

Berty,

Hubner

et al. 2024

JER

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“…The formalin-induced pain test was evaluated as previously described [ 22 ], with a slight modification. The mode of administration and animal groups were the same as the acetic acid-induced writhing test.…”

Section: Methodsmentioning

confidence: 99%

Optimization for ultrasonic-microwave synergetic extraction of total iridoid glycosides and screening of analgesic and anti-inflammatory active fractions from patrinia scabra Bunge (Valerianaceae)

Deng

et al. 2022

BMC Complement Med Ther

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Background Patrinia scabra Bunge is a well-known herbal medicine for its favorable treatment on inflammatory diseases owing to its effective ingredients, in which iridoid glycoside plays an extremely significant role. This article aimed to improve the content of total iridoid glycosides in crude extract through a series optimization of extraction procedure. Moreover, considering that both pain and inflammation are two correlated responses triggered in response to injury, irritants or pathogen, the article investigated the anti-inflammatory and analgesic activities of P. scabra to screen out the active fraction. Method P. scabra was extracted by ultrasonic-microwave synergistic extraction (UMSE) to obtain total iridoid glycosides (PSI), during which a series of conditions were investigated based on single-factor experiments. The extraction process was further optimized by a reliable statistical method of response surface methodology (RSM). The elution fractions of P. scabra extract were prepared by macroporous resin column chromatography. Through the various animal experiment including acetic acid-induced writhing test, formalin induced licking and flinching, carrageenan-induced mice paw oedema test and xylene-induced ear edema in mice, the active fractions with favorable analgesic and anti-inflammatory effect were reasonably screen out. Results The content of PSI could reach up to 81.42 ± 0.31 mg/g under the optimum conditions as follows: ethanol concentration of 52%, material-to-liquid ratio of 1:18 g/mL, microwave power at 610 W and extraction time of 45 min. After gradient elution by the macroporous resin, the content of PSI increased significantly. Compared with other concentrations of elution liquid, the content of PSI in 30 and 50% ethanol eluate was increased to reach 497.65 and 506.90 mg/g, respectively. Owing to the pharmacology experiment, it was reasonably revealed that 30 and 50% ethanol elution fractions of P. scabra could relieve pain centrally and peripherally, exhibiting good analgesic and anti-inflammatory activities. Conclusion Patrinia scabra possessed rich iridoids and exhibited significant analgesic and anti-inflammatory activities.

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Topical gel containing phenolic-rich extract from Ipomoea pes-capre leaf (Convolvulaceae) has anti-inflammatory, wound healing, and antiophidic properties

Xavier-Santos

Gomes

Cruz

et al. 2022

Biomedicine & Pharmacotherapy

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Topical and systemic use of Joannesia princeps vell. LC seed oil in acute pain and inflammation induced by different agents

Cited by 4 publications

References 31 publications

Confirmation, Through Structural Modifications, of Tri-Acyl-Glyceride (TAG) Obtained by Extraction from the Seed of Joanesia princeps (Cutieira a Euphorbiaceae)

Confirmation, Through Structural Modifications, of Tri-Acyl-Glyceride (TAG) Obtained by Extraction from the Seed of Joanesia princeps (Cutieira a Euphorbiaceae)

Optimization for ultrasonic-microwave synergetic extraction of total iridoid glycosides and screening of analgesic and anti-inflammatory active fractions from patrinia scabra Bunge (Valerianaceae)

Topical gel containing phenolic-rich extract from Ipomoea pes-capre leaf (Convolvulaceae) has anti-inflammatory, wound healing, and antiophidic properties

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