Purpose:Imatinib is an efficacious drug against chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) due to selective inhibition of c-KIT and BCR-ABL kinases. It presents almost complete bioavailability, is eliminated via P450-mediated metabolism and is well tolerated. However, a few severe drug-drug interactions have been reported in cancer patients taking acetaminophen.Materials and Methods:Male ICR mice were given 100 mg/kg single dose of imatinib orally or imatinib 100 mg/kg (orally) coadministered with acetaminophen intraperitoneally (700 mg/kg). Mice were euthanized at predetermined time points, blood samples collected, and imatinib plasma concentration measured by HPLC.Results:Imatinib AUC0-12 was 27.04 ± 0.38 mg·h/ml, Cmax was 7.21 ± 0.99 mg/ml and elimination half-life was 2.3 hours. Acetaminophen affected the imatinib disposition profile: AUC0-12 and Cmax decreased 56% and 59%, respectively and a longer half-life was observed (5.6 hours).Conclusions:The study shows a pharmacokinetic interaction between acetaminophen and imatinib which may render further human studies necessary if both drugs are administered concurrently to cancer patients.
The present study was undertaken to develop a rat model for monitoring the early development of breast cancer. Twelve female rats were divided into two groups of six rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer or with bacterial lipopolysaccharide to induce inflammation. Serum samples taken from the rats prior to the treatment were used as controls. By the 14th week, presence of the tumor was detectable by contrast enhanced magnetic resonance imaging and confirmed by histopathology. When the serum proteins of the rats were examined by 2-dimensional electrophoresis (2-DE), no difference could be detected in the profiles of all proteins before and 18 weeks after administration of N-methyl-N-nitrosourea. However, higher expression of alpha-1B glycoprotein was detectable by 2-DE in serum samples of rats at the 18th week post-treatment with lipopolysaccharide.
Common location of teratomas in children are sacrococcygeal, gonadal, mediastinal and retroperitoneal, but teratomas may also occur at very unusual locations. A one-year-old girl presented with a large swelling at her left abdomen. Clinical examination revealed a solitary, non-tender, soft to firm, irregular cystic mass, occupying her left abdominal region. Computed Tomography (CT) scan finding was consistent with retroperitoneal teratoma. Complete surgical excision of the tumour was done without any difficulties. Histology of the excised tumour was conclusive of mature cystic teratoma.
Metastasis to Pituitary gland is an extremely rare condition. Patients are usually asymptomatic and imaging studies often miss the lesion. Pituitary metastases so far reported are largely from autopsies done for unrelated reasons. Here, we describe a case of pituitary metastasis, presented with diabetes insipidis, underwent surgery for removal of pituitary tumor and diagnosed as metastatic lung cancer using immunohistochemical studies.
Small cell glioblastoma (SCGBM) is a rare variant with monomorphous cells and deceptively bland nuclei and are often misdiagnosed. Here, we present a case of small cell GBM in a 39-year-old male involving bilateral basal ganglia diagnosed as primary central nervous system lymphoma on MRI. After excision, the tumor showed features of small cell glioblastoma. Clinical features, morphological characteristics and immunohistochemical features of this rare lesion is hence discussed.
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