Individuals with mild cognitive impairment (MCI) are at high risk of developing into dementia (e. g., Alzheimer's disease, AD). A reliable and effective approach for early detection of MCI has become a critical challenge. Although compared with other costly or risky lab tests, electroencephalogram (EEG) seems to be an ideal alternative measure for early detection of MCI, searching for valid EEG features for classification between healthy controls (HCs) and individuals with MCI remains to be largely unexplored. Here, we design a novel feature extraction framework and propose that the spectral-power-based task-induced intra-subject variability extracted by this framework can be an encouraging candidate EEG feature for the early detection of MCI. In this framework, we extracted the task-induced intra-subject spectral power variability of resting-state EEGs (as measured by a between-run similarity) before and after participants performing cognitively exhausted working memory tasks as the candidate feature. The results from 74 participants (23 individuals with AD, 24 individuals with MCI, 27 HC) showed that the between-run similarity over the frontal and central scalp regions in the HC group is higher than that in the AD or MCI group. Furthermore, using a feature selection scheme and a support vector machine (SVM) classifier, the between-run similarity showed encouraging leave-one-participant-out cross-validation (LOPO-CV) classification performance for the classification between the MCI and HC (80.39%) groups and between the AD vs. HC groups (78%), and its classification performance is superior to other widely-used features such as spectral powers, coherence, and the complexity estimated by Katz's method extracted from single-run resting-state EEGs (a common approach in previous studies). The results based on LOPO-CV, therefore, suggest that the spectral-power-based task-induced intra-subject EEG variability extracted by the proposed feature extraction framework has the potential to serve as a neurophysiological feature for the early detection of MCI in individuals.
Classification between individuals with mild cognitive impairment (MCI) and healthy controls (HC) based on electroencephalography (EEG) has been considered a challenging task to be addressed for the purpose of its early detection. In this study, we proposed a novel EEG feature, the kernel eigen-relative-power (KERP) feature, for achieving high classification accuracy of MCI versus HC. First, we introduced the relative powers (RPs) between pairs of electrodes across 21 different subbands of 2-Hz width as the features, which have not yet been used in previous MCI-HC classification studies. Next, the Fisher’s class separability criterion was applied to determine the best electrode pairs (five electrodes) as well as the frequency subbands for extracting the most sensitive RP features. The kernel principal component analysis (kernel PCA) algorithm was further performed to extract a few more discriminating nonlinear principal components from the optimal RPs, and these components form a KERP feature vector. Results carried out on 51 participants (24 MCI and 27 HC) show that the newly introduced subband RP feature showed superior classification performance to commonly used spectral power features, including the band power, single-electrode relative power, and also the RP based on the conventional frequency bands. A high leave-one-participant-out cross-validation (LOPO-CV) classification accuracy 86.27% was achieved by the RP feature, using a simple linear discriminant analysis (LDA) classifier. Moreover, with the same classifier, the proposed KERP further improved the accuracy to 88.24%. Finally, cascading the KERP feature to a nonlinear classifier, the support vector machine (SVM), yields a high MCI-HC classification accuracy of 90.20% (sensitivity = 87.50% and specificity = 92.59%). The proposed method demonstrated a high accuracy and a high usability (only five electrodes are required), and therefore, has great potential to further develop an EEG-based computer-aided diagnosis system that can be applied for the early detection of MCI.
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