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Background: Acute viral respiratory infections (VRI) are the most common diseases in humans and are associated with high morbidity and mortality in infants and the elderly. Children with congenital heart disease (CHD) are more susceptible to get severe forms of VRI due to their altered lung mechanics, leading to several complications, such as increased hospital stay, longer mechanical ventilation, and higher mortality. This study aimed to identify the frequency of VRI in children with CHD undergoing cardiac surgery, and to compare the major outcomes according to the presence or absence of a VRI. Methods: This was a longitudinal, observational cohort study. Nasopharyngeal secretion samples were collected pre-and postoperatively for patients undergoing cardiac surgery, from May 2013 to May 2014. Respiratory viruses were detected using CLART Pneumovir®. Results: Forty-eight patients were enrolled. We found a VRI preoperatively in 16 children with CHD before surgery (33.3%), and the frequency of new infections was 8.3% (4 patients). However, in this study, in univariate analyses, the two groups did not differ in any of the studied outcomes. In the multivariate regression models, adjusting for age and STAT category, the presence of a VRI did not show a significant effect on the major outcomes. Conclusions: In conclusion, VRI was frequent in children undergoing open-heart surgery, but the presence of a VRI did not impact on major outcomes in this cohort.

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Agradeço primeiramente a Deus, por me iluminar, me proteger e por sempre colocar pessoas especiais em minha vida. À minha esposa, Livia, por me acompanhar, apoiar e por sempre estar presente em todos os momentos da minha vida. Aos meus pais, por serem a minha base, pela educação e pelo exemplo de caráter. Aos meus avós, pelo carinho e amor incondicional e por serem exemplo de humildade e simplicidade. Ao meu mais novo amor, meu afilhado João. Aos meus amigos, mesmo que em alguns momentos não possamos estar presente fisicamente, porém sempre estamos próximos espiritualmente. Ao Dr. Fabio, pelas oportunidades, por exemplo de dedicação, pela paciência e pelos ensinamentos. A equipe do laboratório de pediatria, a equipe do CTIP e equipe de fisioterapia pelo apoio no trabalho. RESUMO Silva, TH. Epidemiologia das infecções virais respiratórias em crianças submetidas à cirurgia cardíaca. 2015. 72f. Dissertação

Silva, TH. Aerosolized lidocaine does not confer benefit as an add-on therapy to reduce respiratory therapy-associated pain after pediatric congenital heart surgery: a randomized, double-blind, placebo-controlled trial. 2021. 30 p. Thesis