Summary: Acetylcholinesterase levels were determined in cerebrospinal fluid and serum of 272 patients with various neurological disorders. The patients were ordered in 13 diagnostic groups. The assay employed was an antigen capture assay based on an immobilized monoclonal antibody selective for neuronal acetylcholinesterase (Rasmussen et al., Clin. Chim. Acta 166 (1987) 17-25 (1)).In 100% of the cases the acetylcholinesterase levels in cerebrospinal fluid were 500-10000 fold higher than expected for a regulär serum-derived protein (0.1 -0.5%) at the intact blood-brain barrier. In both compartments the test vahies showed w'ide variations, which were much greater in serum than in cerebrospinal fluid. No specific relationship was discernible between the values obtained and any of the diagnostic groups, although decreased levels of acetylcholinesterase were found in bacterial and viral meningitis, and elevated levels were found in groups with more chronic diseases.
Remote sensing from space is an emerging market for applications in security, climate research, weather forecast, and global environmental monitoring, to mention a few. In particular, next generation systems demand for large, twodimensional arrays in the short (SWIR, 0.9-2.5 µm) and the very long wavelength infrared (VLWIR) spectral range up to 15 µm. AIM's developments for space applications benefit from AIM's experiences in high-performance thermal imaging and seeker-head applications. AIM has delivered a 13 µm cut-off demonstrator for a high resolution Fouriertransform imaging spectrometer in limb geometry. For this 256 x 256 VLWIR sensor we measured a responsivity of 100 LSB/K and a noise equivalent temperature difference of 22 mK with 14 bit ADCs at 880 Hz full frame-rate. The substrate and epitaxial layer grown at AIM exhibit very good uniformity and low dark currents. Currently, AIM develops a 1024 x 256 SWIR detector (0.9-2.5 µm) with a capacitance transimpedance amplifier (CTIA) for hyperspectral imaging. The radiation hardness of AIM's FPA technology (MCT sensor and Silicon read-out integrated circuit) has been successfully tested by a total ionization dose (TID) experiment using ESTEC's 60 Co γ-source. Our reference module withstands 30 krad TID. For enhanced reliability of the IDCA, AIM has developed a compact 1 W pulse-tube cooler with flexure bearing compressor, which induces also a very low vibration output. In summary, AIM will be able to supply space qualified detector modules covering the spectral range from 0.9 to 13 µm in the near future.
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