Population control is very important for individual and national welfare. Although various synthetic contraceptive agents are available, their use is associated with severe side effects. Therefore, an approach is taken to identify new antifertility agents from natural sources. This study was conducted to determine the effect of areca nut extract on estradiol levels and the estrus cycle of female balb / c mice. The experimental animal models used were fifteen adult female balb / c mice, aged 8-12 weeks, weight 20-40 g and induced for 1 week with water extract of areca nut with a dose of 1 g / 200 g body weight of mice (K1), 2 g / 200 g of body weight of mice (K2) and distilled water in the control group (K0). The estrus cycle was identified by a daily assessment of the relative ratio of nucleated epithelial cells, cornified squamous epithelial cells and leukocytes found at the time of vaginal swabs for 15 days continuously. At the proestrus stage blood is taken from the tail. Serum estradiol levels were determined by ELISA technique. There was a decrease in serum estradiol levels in the treatment group 1 (K1) 1.9 times compared to the control group (K0) and decreased estradiol levels in the treatment group 2 (K2) 5.29 times compared to the control group (K0). Changes in the duration of the estrus cycle occurred in treatment group 1 (K1) to be elongated and treatment group 2 (K2) became non-estrus, while the control group (K0) did not change the duration of the estrus cycle (normal). The decrease in serum estradiol levels affects the estrus cycle of mice (P = 0,000). The administration of areca nut extract has the effect of reducing serum estradiol levels and disrupting the duration of the estrous cycle of female balb / c mice. This finding has important implications for the development of contraception in women.
Hypertension is known as the silent killer because it cannot be predicted and kills slowly. It is estimated that one in 7 causes of death is caused by hypertension (7 million per year). Hypertension can be prevented and maintained by consuming herbal medicines, one of which is rosella and celery. In this analysis, the efficacy of the rosella and hypertension celery mixture in the Matraman sub-district of Puskesmas, was determined. The method of study was pre-test and post-testing with control experimental one-group configuration. The sample size was 05 people and computerized statistical tools used to analyze t combined with. Results showed a blend of rosella and celery infusion, but this was not important, as regional pressure decreased both systole and diastole. Significant systole and diastole values 0.196 and 0.308 > 0.05 are indicated in this context.
In Indonesia, hypertension is the third leading cause of death, following only stroke and tuberculosis. It is a degenerative condition in the elderly, and with growing age, nearly all feel a rise in blood pressure. Taking an infusion of rosella flowers (Hibiscus sabdariffa Linn) in the morning and evening will reduce blood pressure. Contain phytochemicals that can help lower blood pressure. This study aims to see how successfully giving rosella flower infusion (hibiscus sabdariffa linn) against hypertension in the elderly at the Matraman District Health Center. The experimental one-group pre-and post-test configuration with control was used in the analysis. The sample size was 10 people and used comparative analysis with paired t-test using computerized statistical software. The results showed that the decrease in blood pressure using the infusion of rosella flowers was smaller than the amlodipine treatment. This indicates that steeping Rosella does not have a significant effect on hypertension.
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