No abstract

Clinical trials are of utmost importance to establish the validity of such strategies.

Atraumatic splenic rupture is an uncommon complication of acute pancreatitis. This report describes the case of a 30-year-old man with acute pancreatitis and splenic vein thrombosis complicated by splenic rupture. The patient was admitted to the emergency department with pain in the upper abdomen that had been present for six hours and was associated with vomiting and sweating. He was diagnosed with acute pancreatitis of alcoholic etiology. Upon computed tomography (CT) of the abdomen, the pancreatitis was scored as Balthazar C grade, and a suspicious area of necrosis affecting 30% of the pancreas with splenic vein thrombosis was revealed. Seventy-two hours after admission, the patient had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic hematoma and contrast extravasation along the spleen artery. The patient subsequently underwent laparotomy, which showed hemoperitoneum due to rupture of the splenic parenchyma. A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage.

SUMMARY OBJECTIVE Assess the impact of COVID-19 on medical students’ internships in public and private institutions in Brasil, in addition to estimating the quality of the measures taken by their respective Universities in the face of the problem and the availability of personal protective equipment (PPE). METHODS A descriptive cross-sectional quantitative analysis study carried out with 317 students undergoing medical internship from March 31, 2020, to April 12, 2020. The survey was conducted through an online questionnaire using the SurveyMonkey tool with 20 questions. Interns from the fourth to the sixth year of medical schools in the country were randomly included in the study through a survey sent by Whatsapp application. Statistical analysis was performed using the Chi-Square, considering p <0.05 as significant. RESULTS Four main topics were identified in the research: student demographic data; how classes and courses are being taught; the use and ease of access to personal protective equipment and the students’ fears and perspectives for the future. CONCLUSION The study clarified that although half of the students still have some degree of content and, in their majority, they are satisfied, there is still a lot of difficulty in obtaining personal protective equipment, which prevents students from returning safely to their internships.

Pentoxifylline significantly attenuated histologic lung injury, pulmonary neutrophil activity, and proinflammatory signaling in a severe model of AP. Therefore, PTX may serve as an adjunct for the treatment of the inflammatory complications of severe AP.

Collectively, the attenuation of pulmonary inflammation with HSPTX after shock when compared with RL is associated with downregulation of neutrophil activation, oxidative stress, and proinflammatory mediator production.

RESUMO -O aumento da expectativa de vida faz com que os idosos sejam a faixa etária com maior crescimento. A colecistectomia é a cirurgia abdominal mais comum neste grupo. A associação de doenças crônicas e formas complicadas implica em preconizar o tratamento operatório eletivo nos idosos sintomáticos. Os bons resultados obtidos com a colecistectomia laparoscópica determinaram o surgimento de estudos comparando a cirurgia convencional com a videocirurgia, entretanto, nos idosos há poucas casuísticas analisadas, principalmente no nosso meio.OBJETIVOS. Analisar os resultados imediatos da morbidade da colecistectomia eletiva em doentes idosos, por duas vias de acesso.MÉTODOS. Estudamos, retrospectivamente, doentes com idade > 65 anos operados por incisão subcostal (grupo I) e videolaparoscópica (grupo II). Os grupos foram comparados em relação à presença de complicação até 30 dias e nas suas formas de apresentação: cirúrgica, cirúrgicas (intra e pós-operatórias) e sistêmicas e, posteriormente, com as variáveis sexo, faixa etária, doença associada, cardiovascular, metabólica, pulmonar e ASA. Na análise estatística, empregou-se o teste t de Student e a correlação de Spearman, considerando p < 0,05 como significância estatística. RESULTADOS. Foram 246 doentes distribuídos em dois grupos, INTRODUÇÃOA população de idosos é a que apresenta a maior projeção de crescimento mundial. No Brasil, estima-se o aumento dos idosos de 7,5 para 30 milhões em 2020, ocasião na qual o país terá a sexta população de idosos do planeta 1 . Em decorrência das características especí-ficas dos países de clima tropical, considera-se idoso o indivíduo acima de 60 anos de idade 2 . Entretanto, na literatura internacional, a idade de 65 anos é mais aceita [3][4][5][6][7][8][9][10][11][12][13][14] .A diminuição das reservas funcionais e a presença de doenças associadas em cerca da metade dessa população estabelecem um grupo de doentes com maior complexidade clínica. Concomitante às doenças crônicas, algumas enfermidades de tratamento cirúrgico apresentam aumento de incidência com a progressão da idade 15 . A colelitíase é a doença cirúrgica abdominal mais comum no doente idoso, sendo sua incidência relacionada à progressão da idade, com prevalência global de 9,3%; passando para 21,4% nos idosos de 60 a 69 e, na faixa etária acima de 70 anos, acomete 27,5% dos indivíduos 16 . As colecistectomias atualmente realizadas nessa população variam de 8,3% a 24% 6,7,12,13,18 . E, com publicações enfatizando o aumento de cirurgias em octagenários [19][20][21] .

The attenuation in gut injury after postshock resuscitation with HSPTX is associated with downregulation of iNOS activity and subsequent proinflammatory mediator synthesis. HSPTX has the potential to be a superior resuscitation fluid with significant immunomodulatory properties.