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Objectives. Atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignant pediatric brain tumor, characterized by inactivation of INI1/hSNF5 gene and loss of its protein. We studied the histomorphological and immunohistochemical spectrum of this tumor including cyclin D1 expression and MYC gene amplification. Methods. Cases with INI1 loss by immunohistochemistry (IHC; from 2005 to 2018) were retrieved, reviewed, and evaluated for cyclin D1 expression by additional IHC and fluorescence in situ hybridization for MYC genes. Results. A total of 66 cases were identified. Age ranged from 1 to 20 years (≤3 years, 44 cases; >3 years, 22). Male to female ratio was 1.7:1. Tumor locations were as follows: posterior fossa: 30; supratentorial: 31; spinal: 5. AT/RT in patient ≤3 years was frequently located in the posterior fossa, composed of primitive embryonal morphology ( P = .02), rarely had ample rhabdoid cells ( P = .05), and had a negative impact on overall survival ( P = .04). The rhabdoid cells was a conspicuous component of posterior fossa tumors compared with the supratentorial ones ( P = .06). The supratentorial tumors ( P = .06), absence of rhabdoid cells ( P = .06), and the presence of immunological divergent differentiation ( P = .11) had a comparatively better outcome. Cyclin D1 overexpression (n = 46) was noted in 32 cases and was frequently seen in the posterior fossa tumors ( P = .02). CMYC (n = 42) amplification was seen in 1 case and the NMYC (n = 42) amplification in none. Conclusion. AT/RT can occur in the noninfantile age group, at nonconventional sites and frequently overexpress cyclin D1. The MYC alterations are almost nonexistent in AT/RT.

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Neurofibromas (NF) are seen either as a solitary lesion or as part of the generalized syndrome of NF (NF-1, also known as von Recklinghausen disease of the skin). In plexiform neurofibroma (PN), there is a proliferation of Schwann cells from the inner aspect of the nerve sheath, thereby resulting in an irregularly thickened, distorted, and tortuous structure. Oral involvement by a solitary and peripheral PN in patients with no other signs of NF is rarely seen. It is reported that only 4-7% of patients affected by NF display oral manifestations. A solitary PN in a patient with no other symptoms is a diagnostic challenge, more so when the location of the lesion is one of the rarest sites.

Cervical cancer is one of the leading causes of mortality and morbidity in women worldwide. Invasive cervical carcinomas are preceded by a stage in which the abnormal cells are confined to the epithelium (Intraepithelial stage). Women can be routinely screened for intraepithelial stage with cervical cytology smears and hence invasive stage can be prevented by early diagnosis. Cervical cytology smears also an useful tool in aiding the diagnosis of infectious and inflammatory conditions of the cervix. Objectives: To evaluate the cytomorphological spectrum of cervical smears referred to a tertiary hospital. Materials and Methods: It is a retrospective observational study. Clinical data and pap smear cytology reports were obtained from the archives during the period of May 2018-May 2019(1 year study). All smears were reported as per "Bethesda system of reporting cervical cytology " 2001. Results : A total of 1241 cases were examined. The age group of patients ranged between 18yrs to 75 yrs. A total of 1203 cases (97%) were reported as Negative for intraepithelial lesions/malignancy, out of which 124 cases(0.1%) showed vaginal candidiasis, 56 cases (0.05%) were reported as Trichomonas vaginalis infection, 321 cases (0.26%) as Bacterial vaginosis, 1 case of HSV infection associated changes, 67 cases(0.05%) were reported as inflammatory smears. 38 cases showed abnormality, out of which 29 cases were of ASC-US,3 cases of LSIL, 3 cases were reported as HSIL, 2 cases as Squamous cell carcinoma and 1 case with adenocarcinoma cervix. Conclusion: Cervical inflammatory lesions (including infections) and neoplastic lesions (includes intraepithelial and epithelial malignancies) can be diagnosed by Cervical cytological smears.

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