Mediastinal tumors are considered to be mediastinal disease with various clinical and histopathologic presentations. In Indonesia, literatures concerning mediastinal tumors are still few. This study aims to obtain the characteristic of mediastinal tumors in Dr.Hasan Sadikin Hospital. A cross-sectional retrospective study was conducted using medical records from 2011 to 2016. All medical records with clinical diagnosis of mediastinal tumors are included, and cases with metastatic tumors from distant sites to the mediastinum, and/or incorrect histopathologic findings are excluded. We obtain data of age, gender, clinical symptoms, histopathologic finding, and staging, with total samples collected of 72. We find out that patients with mediastinal tumors are mainly over 40 years old (62.5%), especially in the 6th decade of life (23.6%), and were mostly of males (73.6%). Patients mainly had chief complaints of dyspnea (38.7%), followed by cough and typical myasthenia gravis symptoms. The most common type of mediastinal tumor is epithelial cell tumor (68.4%), and the most common stage is Masaoka-Koga stage III (37.5%). This study concludes that mediastinal tumor mainly occurs in males aged 40 years old and above, with epithelial cell tumor as the most common histopathologic findings.Keywords : characteristics; mediastinal tumor; mediastinum

Background:As one of the most devastating complication in diabetes mellitus

Background: Inflammation is a normal response that potentially harmful if it is uncontrolled. On the other hand, it is necessary to find an alternative anti-inflammatory as most anti-inflammatory drugs available nowadays still have adverse effects. Trigona spp. propolis is one of the potential anti-inflammatory alternatives because of its flavonoid, especially caffeic acid phenethyl ester, which is known as an active compound in anti-inflammatory process. This study aimed to understand the anti-inflammatory effect of Trigona spp. prolisin reducing edema volume in rat's paw. Methods: An experimental study was performed on 20 male wistar rats. The rats were divided into control and experimental groups with 10 rats in each group. Control group was treated by propylene glycol 1 ml/day and experimental group was treated by Trigona spp. propolis 200 mg/kg body weight/day. The inflammation was induced by subcutaneous injection of λ-carrageenan 1% at plantar one hour after the treatment. Edema volumes were measured by plethysmometer every hour at 1 to 6 hours and once at 24 hours after induction. The difference in edema volumes was calculated in percentage. This study was conducted during October 2012 at the Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran Bandung. Results: The increase of edema volume (in percentage) in control group and Trigona spp. propolis treated group are 100.64±32.22 and 56.46±20.38 respectively (p value=0.000). Multiple comparisons using Dunnet and Duncan post hoc test showed significant differences that were observed at 3, 4, 5, and 6 hours after inflammatory induction. Conclusion: Trigona spp. propolis has an anti-inflammatory effect in reducing edema volume in rat's paw. The most significant effect was observed at 3, 4, 5, and 6 hours after inflammatory induction. Trigona spp. propolis might have a potential to be developed as a future anti-inflammatory drug.

Background: Chronic vein diseases are quite common and its prevalence is also quite high in community. One of the risk factors is occupation with prolonged standing. Quality of life and work efficacy may become risk factors. This disease has not received any special consideration and response. Methods: This is a cross-sectional study performed on nurses working in Dr. Hasan Sadikin General Hospital Bandung (n=98; women=76, men=22). The study was conducted in November 2012 through collecting data on prevalence, risk factors, and clinical symptoms by using questionnaire. Chronic venous disease was observed by direct inspection in lower extremities. Diagnosis was concluded according to the Clinical Etiology Anatomy Pathophysiological criteria. Results: There was a high frequency, i.e. 86.7% (n=71), of chronic venous disease among nurses, with the age group of 20-29 years old (34.1%) as the age group that was mostly affected. Among female nurses, almost all of them experienced the disease (93.4%; n=71). Clinical symptoms felt by most nurses were heavy feeling on legs (82.3%) and cramps (55.3%). Conclusion: The frequency of chronic venous disease among nurses is high, 86.7% and almost all of the female nurses suffer from the disease. The high frequency in females could be caused by risk factors such as parity and hormonal contraception. Those who are mostly affected by the disease are within range of age 20-29 years old of age. Heavy legs and cramps are the most frequent clinical symptoms felt.

Deep vein Trombosis (DVT) merupakan suatu kondisi terbentuknya bekuan darah pada sistem sirkulasi vena dalam yang dapat menyebabkan emboli paru yang berujung kematian. Salah satu penyebab terjadinya DVT adalah stasis aliran darah akibat tirah baring lama. Penelitian ini bertujuan untuk mengetahui hubungan tirah baring lama (lebih dari 7 hari) dengan kemungkinan terjadinya DVT pada pasien yang dirawat di bangsal perawatan bedah RSUP Dr. Hasan Sadikin dengan melakukan pemeriksan USG kompresi dan pemeriksaan DDimer. Penelitian ini dilakukan dengan metode kohort prospektif observasional. Hasil penelitian menunjukkan dari 67 subjek penelitian, terdapat 44 pasien yang memenuhi kriteria inklusi, 57% diantaranya laki-laki. Rerata lama rawat adalah 12 hari. Hasil uji korelasi Spearman didapatkan r=0,000 yang artinya tidak terdapat korelasi antara tirah baring lama (2 minggu) dengan risiko terjadinya DVT. Kesimpulan dari penelitian ini tidak terdapat hubungan tirah baring lama dengan terjadinya DVT pada pasien-pasien yang dirawat di ruang rawat bedah RSUP Dr. Hasan Sadikin Bandung.