Direct asymmetric α-chlorination of aryl acetic acid derivatives was achieved with a novel trinary activation system consisting of a catalytic amount of NiCl 2 /(R)-BINAP, Et 3 SiOTf, and a tertiary amine base. The reaction smoothly af-
Catalytic Asymmetric α-Chlorination of 3-Acyloxazolidin-2-one with a Trinary Catalytic System. -A trinary catalytic system allows asymmetric chlorination of aryl acetic acid derivatives in good yield with up to 89% e.e. Notably, γ-deprotonation and α-chlorination of the α,β-unsaturated compound (III) also occur with this system. The masking oxazolidone can be removed by LiOH/H2O2 hydrolysis without loss of optical purity. -(HAMASHIMA, Y.; NAGI, T.; SHIMIZU, R.; TSUCHIMOTO, T.; SODEOKA*, M.; Eur.
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