ChemInform Abstract: Catalytic Asymmetric α‐Chlorination of 3‐Acyloxazolidin‐2‐one with a Trinary Catalytic System.

Abstract

Catalytic Asymmetric α-Chlorination of 3-Acyloxazolidin-2-one with a Trinary Catalytic System. -A trinary catalytic system allows asymmetric chlorination of aryl acetic acid derivatives in good yield with up to 89% e.e. Notably, γ-deprotonation and α-chlorination of the α,β-unsaturated compound (III) also occur with this system. The masking oxazolidone can be removed by LiOH/H2O2 hydrolysis without loss of optical purity. -(HAMASHIMA, Y.; NAGI, T.; SHIMIZU, R.; TSUCHIMOTO, T.; SODEOKA*, M.; Eur.