High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged >33 and <37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P<0.0001) and with neonates from GI and GII (P<0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P<0.01) and lower in GII (P<0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for O111 in GI (P<0.05) and for O26 and Pseudomonas in GII, both as compared with GIII (P<0.05). The anti-lipopolysaccharide IgG transfer ratios were lower in GI (except for O26) and in GII (except for Klebsiella and O111) as compared with GIII (P<0.05). Our results suggest that the greater susceptibility to infections in preterm infants is influenced (besides the humoral response) by factors intrinsic and extrinsic to the condition of prematurity.
The responsiveness of two health related quality of life tools indicates their relative sensitivity for assessing clinical improvement during active treatment in Juvenile Idiopathic Arthritis patients.\par
ResumoObjetivo: estudar o impacto da artrite crônica na qualidade de vida relacionada à saúde, por meio de dois instrumentos autoaplicáveis: a versão destinada aos pais do Childhood Health Assessment Questionnaire (CHAQ) e do Child Health Questionnaire (CHQ) PF50 ® .Método: os dois questionários foram respondidos por 36 pais, após instruções durante 1 a 2 visitas clínicas, sendo os índices da Capacidade Funcional (CHAQ), Físico e Psicossocial (CHQ) comparados com as medidas essenciais de atividade da doença: (1) a avaliação global pelo médico, (2) a avaliação global pelos pais, ambas em escala analógica visual de 10 cm, (3) o número de articulações ativas, (4) o numero de articulações com limitação dos movimentos, (5) a velocidade de hemossedimentação.Resultados: houve diferença significante entre os grupos oligoarticular e poliarticular, sendo os índices de atividade maiores no poliarticular, com exceção da velocidade de hemossedimentação, avaliação global pelos pais e índice psicossocial, confirmando diferentes níveis de percepção pelos pais sobre a atividade e prognós-tico. A melhor responsividade estatística frente à intervenção terapêutica, em duas visitas consecutivas, foi a medida da avaliação global pelo médico entre as subjetivas, tendo as medidas avaliadas por instrumentos de responsividade intermediária, quando comparadas com o numero de articulações ativas, número de articulações com limitação dos movimentos e a velocidade de hemossedimentação.Conclusão: a medida da responsividade de dois instrumentos de avaliação funcional e da qualidade de vida indicou a sua sensibilidade relativa para estimar a melhora clínica em pacientes com artrites idiopáticas juvenis, recebendo tratamento específico.J Pediatr (Rio J) 2003;79(1):63-8: artrites idiopáticas juvenis, qualidade de vida relacionada à saúde, avaliação funcional, instrumentos auto-aplicáveis, prognóstico. AbstractObjective: to study the impact of chronic arthritis on health related quality of life by means of two self-reported tools: the parents' version of the Childhood Health Assessment Questionnaire (CHAQ) and the Childhood Health Questionnaire PF50 ® (CHQ).Methods: both tools were filled in after proper instructions by 36 parents, during 1-2 clinic visits. The Disability Index (CHAQ) and the Physical and Psychosocial scores (CHQ) were compared to the core set of outcome measures, namely 1) physician's global assessment, 2) parents' global assessment, both scored by 10 cm visual analogue scale, 3) number of joints with active arthritis, 4) number of joints with limited range of motion, 5) erythrocyte sedimentation rate.Results: there was significant difference for all measures of disease activity, being higher in the polyarticular as compared to oligoarticular except for erythrocyte sedimentation rate, parents' global assessment, and psychosocial score. This leads to different parents' perceptions of disease activity and outcome. The responsiveness of the outcome measures during two follow-up visits of patients receiving active treatment indicated...
Biomédicas da USP: Dra.Patrícia e Ana, por toda a ajuda na metodologia. À Marisa Kasue Umetsu Yoshikawa pela colaboração com as referências bibliográficas. Ao meu marido pela compreensão e apoio. Aos meus pais e irmão pelo incentivo da vida toda. "Felicidade é ter algo o que fazer, ter algo que amar e algo que esperar".
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.