Thing. The significance of the study is associated with high prevalence of inflammatory diseases of paradontium and a variety of medications used for systemic treatment of the said pathology. Searching effective approaches aiming to achieve a required and adequate therapeutic effect excluding complications from unwanted effects and toxic side effects of systemic medications assumes the priority application of local delivery systems. Objective ― to study available literature data on local drug delivery systems as film forming transmucoid therapeutic systems in periodontology. Methodology. The study was based on searching and examination of scientific publications on film forming transmucoid therapeutic systems in databases of PubMed, eLIBRARY, Scopus, Web of Sciens, Medline. The materials were searched by the key words. Results. The review presents research data of different authors, explains the definition of transmucoid therapeutic systems, offers main classifications, describes methods of manufacture of polymer film systems and their characteristics, gives some variants of matrix membrane transport and the most popular representatives of the basement membrane. Conclusions. Studying literature helped to identify the diversity of the range, characteristics and advantages of applying transmucoid therapeutic systems used to treat inflammatory diseases of paradontium. Further detailed polymer researches focused to maintain chemical stability, specifics of diffusion, metabolism, solubility and dose-limiting toxicity are intended to increase safety and efficacy of applied local polymeric film delivery systems.
Subject. Microbial landscape of the oral cavity is a highly sensitive systemic indicator reacting to changes in different body organs and systems by qualitative and quantitative shifts. The unique ability of microbiocenosis of the oral cavity to self-regulate and maintain the ecological balance creates a personal health profile of an individual and assumes that a timely correction of microbiocenosis shall be added to required treatment patterns for various dental and somatic diseases. This approach ensures the protective effect of growth of opportunistic pathogenic bacteria improving quality of therapy and patient recovery time. Objectives. To study dynamics of clinical and microbiological changes in the oral cavity in patients with periodontitis and hypothyroidism on the background of complex therapy with inclusion of synbiotic Maxilac. Materials and methods. Based in the Ural State Medical University Department of Therapeutic Dentistry and Propedeutics of Dental Decease, the study of oral microbiology was carried out on 50 generalized moderate periodontitis patients aged 44 to 59 years during the period from 2017 to 2021. The average age of the subjects was 50.50±3.5 years. Two groups were formed: the main group (30 patients with “primary hypothyroidism” receiving hormone therapy) and the comparison group (20 patients). The patients in the main group were prescribed general therapy by the endocrinologist based on the phase, stage and the severity of the disease. During examination all patients underwent the complex clinical and laboratory evaluation before treatment, in its course and after it, as well they were subjected to full mouth debridement and the course of the complex periodontal therapy in accordance with clinical recommendations. Microbiota was corrected by active ingredient probiotic (lyophilized probiotic bacteria) — 4.5*109 CFU (colony-forming unit): Lactobacillus elveticus, lactis, rhamnosus, plantarum, casei; Bifidobacterium longum, breve, bifidum; Sreptococcus thermophilus. Results. The study of microbiocenosis of the oral cavity of patients with primary hypothyroidism demonstrated changes in species and the number of microorganisms in the oral cavity. Conclusions. Timely diagnostics and correction of disbiotic changes included in the dental treatment protocol will allow to select the most appropriate dental treatment strategy.
Subject. This paper covers the main aspects of non-steroidal anti-inflammatory drugs (NSAIDs) used on periodontal therapy in patients with cormobid pathology. Objectives. A domestic and foreign literature review on effects of NSAIDs on periodontal therapy in patients with cormobid pathology. Methodology. The literature review is based on the source literature available over the past five years starting 2015 by PubMed keywords in order to summarize the subject information. Conclusion. NSAIDs, therefore, remain the most essential medications on etiotropic, pathogenetic and symptomatic therapy of dental disorders. NSAIDs can help manage pain syndrome, control inflammation responses and regeneration with indulating inflammation-induced tissue destruction, prevent unnecessary complications during basic and supportive periodontal therapy including invasive techniques. Systemic and localized use of NSAIDs in the complex periodontal therapy based on the rational choice of the drug and the appropriate dose selection considering patient’s comorbidities must be necessarily supported by the dentist’s knowledge of pharmacodynamics and NSAIDs classifications with Clinical Guidance on rational use of NSAIDs (2015, revised 2018) and Clinical Guidance on comorbid pathology (2019) taken as the basis. These, therefore, will ensure the personified approach, efficacy and safety of NSAID use in patients.
Subject. Modern medical care is not complete without the use of modern digital technologies — from remote patient registration and appointment, to remote diagnostics and laboratory tests, monitoring the condition of the patient. In most foreign countries and Russian medical institutions, telemedicine and digital technologies are actively used in the provision of dental care. The impact of digitalization of medical organizations as part of the transformation of the technological environment on the effectiveness of the organization of dental care services and patient satisfaction. The goal is to study the parameters of psychological resources of subjects of the treatment process that affect the development of digitalization. Develop an initiative to increase the benefits of digitalization in dental care. Methodology. Individual, tutored training in digitalization skills. Group forms of training (seminars, round tables, trainings). Results. Our research has shown that digitalization should start with the registry. This also implies improving the personal qualities and skills of both health professionals and patients. In addition, digitalization should also contribute to the development of comfort in the provision of dental services and improve the quality and safety of medical services provided. Conclusions. A resource-based approach in digital dentistry can be a conscious choice that can improve the efficiency of dental procedures and optimize workflows. In dental practice, saving time for performing auxiliary procedures means reducing the duration of appointments, increasing throughput, and increasing patient satisfaction in General and specific cases.
Object. The paper analyzes the change in the physical and chemical properties of mixed saliva in patients with the course of use of toothpaste "Sensodyne® Recovery and protection" containing NovaMin and sodium fluoride. The analysis of the survey of organoleptic properties of toothpaste, clinical examination of patients with hyperesthesia and laboratory parameters of mixed saliva in dynamics was carried out. Purpose. Rationale for the use of therapeutic and prophylactic toothpaste "Sensodyne® Recovery and protection" with sodium fluoride for sensitive teeth in young patients. Methodology. A clinical examination of the oral cavity of young patients (50 men, mean age of 22.50±2.59 years), index estimation of a condition of the teeth (CPUs, municipal production unitary enterprise), oral hygiene (J. R. Green, J. R. Vermillion, 1964), the determination of "teeth sensitivity" (method L. Y. Nut–Litovskogo S. B.); the study of mixed saliva (qualitative analysis, salumeria; concentration of fluorine ions and sodium, pH, redox potential, total zhestkost) exchange rate before and after application of toothpaste. Results. A pronounced clinical effect was obtained, which manifests itself in the cleansing qualities (p≤0.05), and in the elimination of hyperesthesia (p≤0.05) in all patients. The increase of pH values (p≤0.05) was revealed. After cleaning in the sample of mixed saliva, the concentration of fluoride ions increases by 22%, the content of sodium ions decreases by 35.4%, the content of calcium and magnesium ions decreases. This contributes to the formation of stable fluorapatite Ca5(PO4)3F in the surface layers of enamel. calcium ions from phosphosilicate calcium-sodium (NovaMin) go directly from the toothpaste "Sensodyne® repair and protect" with the sodium fluoride in the construction of the hydroxyapatite of tooth enamel. Summary. Thus, the analysis of the results of the survey evaluation of the organoleptic properties of toothpaste "Sensodyne® Recovery and protection" containing sodium fluoride, which are estimated to be highly valued, clinical examination of patients with hyperesthesia and laboratory parameters of mixed saliva in dynamics, showed a significant clinical effect: improving the cleaning ability of toothpaste, reducing the sensitivity of teeth in 100% of patients.
Background. Aggressive forms of periodontitis are a group of periodontal diseases characterized by rapid development, significant bone loss, few clinical manifestations, weak inflammatory and immune response, a small number of microorganisms, not proportional to the severity of destruction. According to modern ideas about the etiology of aggressive forms of periodontitis, the main reason for their development – the penetration of periodontal tissue Aggregatibacter actinomycetemcomitans. Therefore, aggressive forms of periodontitis may require adjunct antibacterial therapy. Objective ― to determine and analyze the most effective methods of antibiotic therapy in patients with aggressive forms of periodontitis. Methods. A literary review of the studies of Russian and foreign scientists on the development of approaches to improving the effectiveness of antibiotic therapy of aggressive forms of periodontitis in patients, using scientific search library databases PubMed, Medline, Cochrane, Elibrary. The main selection of materials was carried out by keywords. 37 publications were found. Results. The review describes the main methods of modern antibiotic therapy of aggressive forms of periodontitis, the main advantages of antibacterial drugs. Conclusion. In modern periodontics, there is a significant interest in the problem of antibiotic therapy of aggressive forms of periodontitis; various modes of antibiotics are studied. Most studies of this pathology are devoted to the use of moxifloxacin, azithromycin and a combination of amoxicillin and metronidazole. Additional use of antibiotics leads to better results in the treatment of aggressive forms of periodontitis.
Thing. The experience of conducting professional oral hygiene in patients with chronic periodontitis in combination with drug-associated jaw osteonecrosis is presented. The goal is to identify the features of the oral cavity status of patients with chronic periodontitis and bisphosphonate osteonecrosis of the jaw (BONCH) on the background of postoperative chemotherapy after using two domestic mouthwashes (OML). Methodology. A clinical examination of the oral cavity of 15 patients aged 50 to 66 years was carried out, which were divided into two groups: the main group (after resection of the jaw segments) and the comparison group (5 and 10 people, respectively). Dental examination included examination of the oral cavity: the condition of periodontal tissues and mucous membrane, determination of the intensity of dental caries and hygiene and bleeding indices. Studies of mixed saliva (SS) were carried out before and after a single and daily course use of two domestic rinses based on chlorhexidine bigluconate and benzidamine and extracts of medicinal plants. Results. The pH value after the course application of OMLPR-1 in patients with BONCH has shifted from weakly acid (6.45 ± 0.4 units) to slightly alkaline (7.15 ± 0.15 units) medium. The structure of the SS before the application of OPLPR-1 was represented by small conglomerates of irregular shape and individual tree crystals of small sizes, and after the double use of OPLPR-1, the properties of the SS improved and medium-sized tree crystals appeared. After the course application of OPLR-2 in these patients, crystal-prismatic structures of a tree form were identified, a tendency to restore the structural properties of SS was determined. Findings. After the course application of LPRS, a tendency to restore the structural properties of SS was revealed. The course use of CPLR stimulates the excretion of SS, cleansing and a feeling of freshness in the mouth. The consecutive use of OPLR-1 and OPLR-2 helps to alleviate the condition of patients, especially against the background of BONCH and chemotherapy.
Subject. Oral malodour (halitosis) in patients with periodontal disease. Objectives. To study and review the literature on local (dental) and general (internal diseases) factors causing halitosis in patients with periodontal disease. Conclusion. The present literature review provides a sufficient basis to state that the problem of halitosis is relevant; there is presented the overview of developed classifications and identified combinations of main causes of halitosis linking the extent of ozostomia to oral hygiene status and gingival hemorrhage. By modern molecular genetic technologies (polymerase chain reaction and 16S ribosomal RNA gene chipping), advances have been made in understanding the main role of uncultivated anaerobic oral pathogens associated with halitosis. The materials of this literature review help to get the complex idea of the problem of halitosis in patients with inflammatory periodontal disease and can be used by dental clinicians in health care practice.
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