ABSTRAK Cara membatik di Indonesia mulai banyak beralih dari pemakaian bahan alami menjadi bahan cat sintesis. Cat sintetis yang digunakan sering kali mengandung logam berat di antaranya timbal (Pb) dan kromium (Cr). Pemakaian logam berat dalam waktu lama akan mengganggu kesehatan. Penelitian ini dilakukan untuk melihat hubungan kadar logam Pb dan Cr dalam darah dan limbah dengan kadar hemoglobin (Hb) dan Packed Cell Volume (PCV) serta mengetahui prevalensi gejala toksisitas yang dirasakan pada pekerja di tiga sentra batik di Desa Lendah Kulon Progo. Sebanyak 76 pegawai di sentra batik: 37 orang di sentra SB, 20 orang di FA dan 19 orang di SA ditentukan kadar Hb, PCV, kadar Pb dan Cr dengan metode Inductively coupled plasma (ICP). Air limbah lingkungan dari ketiga lokasi sentra batik diambil dan diperiksa kadar Pb dan Cr-nya. Hasil antara ketiga lokasi diuji normalitasnya dan dianalisis dengan analisis varian atau Kruskal-Wallis. Hubungan antara kadar Pb dan Cr baik darah maupun limbah dengan kadar logam berat dalam darah dianalisis dengan uji korelasi Pearson atau Spearman. Hasil dinyatakan berbeda bermakna jika p<0,05. Gejala penyakit yang dialami pekerja yang diperkirakan berhubungan dengan toksisitas logam berat dihitung frekuensinya. Antropometik, tekanan darah, kadar Hb, PCV dan logam berat dari ketiga lokasi yang diperiksa tidak berbeda bermakna (p>0,05). Kadar Pb darah dan krom di sentra SB dan FA berbeda signifikan dengan di sentra SA (p<0,05). Tidak terdapat korelasi yang signifikan secara statistik antara kadar Pb darah, Cr darah, dan Pb limbah dengan kadar Hb dan PCV. Gejala iritasi kulit, pusing, dan nyeri sendi dirasakan 37-49% repsonden. Kadar timbal dan krom darah pembatik di sentra SB dan FA lebih tinggi dari sentra SA. Tidak terdapat hubungan bermakna antara toksisitas Pb dan Cr dengan kadar Hb dan PCV. Gejala toksisitas di antara pekerja batik diperkirakan dapat terjadi karena toksisitas logam berat kronis akibat pemakaian cat batik.KATA KUNCI batik; hemoglobin; chromium; sel darah; timbal ABSTRACT The dye used to color batik has changed from natural to synthetic materials in several places in Indonesia. Synthetic paints often contain heavy metals including lead (Pb) and chromium (Cr). Chronic use of heavy metals can affect health. This study was conducted to examine the relationship between blood and waste water levels of Pb and Cr with hemoglobin (Hb) and Packed Cell Volume (PCV), and to determine how many workers felt the toxicity symptoms in three batik centers in Lendah Kulon Progo. A total of 76 batik center employees: 37, 20, and 19 people from the SB, FA, and SA centers were recruited. Determination of Hb, PCV, Pb and Cr levels were conducted with the Inductively coupled plasma (ICP) method. Wastewater from the three batik centers is taken and examined. The data were analyzed by One-way ANOVA or Kruskal-Wallis. Correlation anayses were performed with Pearson or Spearman correlation test. Results were considered significant if p<0.05. Disease symptoms experienced by workers that are estimated to be associated with heavy metal toxicity are calculated in frequency. Anthropometrics, blood pressure, Hb levels, PCV and heavy metals were not significantly different between centers (p>0.05). Blood Pb and Cr from the SB and FA were significantly different from those at the SA center (p<0.05). There were no statistically significant correlations between blood Pb levels, blood Cr, and Pb waste with hemoglobin and PCV levels. Symptoms of skin irritation, dizziness, and joint pain were felt by 37-49% of respondents. Blood levels of lead and chrome in the SB and FA centers are higher than the SA centers. There was no significant correlation between Pb and Cr toxicity with hemoglobin and PCV levels. Symptoms of toxicity among batik workers are thought to occur due to chronic heavy metal toxicity due to the use of synthetic paint.KEYWORDS batik; haemoglobin; chromium; blood cell; plumbum

BACKGROUND: Obesity is considered associated with an increase of resistin levels that plays a role in the regulation of energy and maintaining fasting blood glucose. Polymorphism of resistin is thought to be correlated with the levels of resistin and insulin resistance.AIM: This study aimed to examine the association of +299G > A and -420C > G resistin (RETN) gene with resistin level and insulin resistance in obese people of Indonesia.METHODS: We examined 142 healthy unrelated subjects consisting of 71 obese and 71 controls. Fasting blood glucose was measured by the enzymatic method while the resistin and insulin levels were measured by Elisa method. Insulin resistance was calculated by HOMA-IR index. Polymorphisms of RETN genes were examined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method, and the data was tested. The data were correlated with Kruskal Wallis continue logistic regression and simple linear regressionRESULTS: In the obese group, there was an increased level of insulin (17.74 vs 11.27 mU/L) and insulin resistance (HOMA-IR 3.9 vs 1.46) compared to the control group. Polymorphism of +299G > A was associated with insulin resistance (GA and GA + AA genotype significantly different compare GG genotype with P < 0.001). Resistin level was negatively correlated with insulin level (P = 0.017). CONCLUSION: In this study, polymorphism of +299G > A was identified as a risk factor for insulin resistance, and there was a significant association of serum resistin level with insulin level in the population of Indonesia.

ABSTRAK Sebagian besar penduduk di daerah pedesaan bertaraf ekonomi menengah ke bawah, memiliki keterbatasan akses informasi, dan memiliki mata pencaharian berbeda dibanding penduduk kota. Bantar Kulon merupakan daerah pedesaan dan Kronggahan adalah daerah perkotaan di Yogyakarta. Mengingat terjadinya pergeseran pola penyakit dari penyakit menular ke penyakit tidak menular serta adanya pengaruh lingkungan dan gaya hidup terhadap terjadinya penyakit degeneratif, dilakukan pengkajian mengenai faktor risiko sindroma metabolik di dua daerah tersebut. Penelitian ini dilakukan untuk mengetahui apakah ada perbedaan kadar glukosa darah puasa (GDP) dan tekanan darah (TD), serta keluhan/ penyakit utama pada penduduk di daerah pedesaan dan perkotaan. Sebanyak 71 orang dari Bantar Kulon dan 91 orang dari Kronggahan diperiksa kadar GDP menggunakan GCU Multi-Function Monitoring System (EasyTouch®). Tekanan darah diperiksa menggunakan sphygmomanometer raksa dan otomatis. Faktor risiko GDP dan TD kedua lokasi ditampilkan dalam bentuk deskriptif berdasarkan cut-off (GDP: ≥100mg/dL; TD: ≥140/90 mmHg). Uji t atau Mann Whitney U dilakukan untuk mengetahui perbedaaan nilai variabel antar kedua lokasi. Hasil dinyatakan berbeda bermakna jika p<0,05. Data keluhan kesehatan ditampilkan secara deskriptif. Tidak ada perbedaan kadar GDP antara desa dan kota (p=0,385). Persentase subjek yang memiliki GDP ≥ 100 mg/dL lebih banyak di kota dibanding desa (42,3% vs 26,4%). Persentase hipertensi berdasarkan pemeriksaan lebih tinggi di kota dibanding desa (50,5% vs 33,8%). Berdasarkan wawancara, keluhan/ penyakit tertinggi pada kedua wilayah adalah hipertensi sebanyak 23 orang (33,82%) di desa dan 30 (32,97%) di kota. Disimpulkan bahwa faktor risiko GDP di atas normal lebih banyak ditemukan di desa sedangkan hipertensi lebih banyak ditemukan di kota. Keluhan/ penyakit utama di kedua wilayah adalah hipertensi.KATA KUNCI kadar glukosa darah; penyakit metabolik; hipertensi; pedesaan; perkotaan             ABSTRACT Most people living in rural areas are from lower to middle income class, have limited access to information, and have different occupations compared to those in urban areas. In Yogyakarta, Bantar Kulon is a rural area, while Kronggahan is an urban area. Currently, the pattern of disease is shifting from infectious diseases to non-communicable diseases with environment and lifestyle factors as determinants. Thus, it is necessary to study the trends of risk factors for metabolic syndrome in both areas. This study aimed to seek the difference of  fasting blood glucose (FBG), blood pressure (BP), and major complaints/illness between rural and urban areas. 71 people from Bantar Kulon and 91 people from Kronggahan were examined for FBG levels using GCU Monitoring System (EasyTouch®). Blood pressures were checked using sphygmomanometer. Risk factors for FBG and BP were presented as frequencies based on cut-offs (FBG: ≥100mg/dL; BP: ≥140/90 mmHg). T-test or Mann-Whitney U test were used to analyze the difference in variables between both areas. Results were significantly different if p <0.05. Health complaint data were displayed descriptively. There was no difference in FBG level between rural and urban areas (p = 0.385). The percentage of subjects with  FBG ≥ 100 mg / dL was higher in Kronggahan than in Bantar Kulon (42.3% vs 26.4%). Based on examination, percentage of hypertension was higher in urban than rural areas (50.5% vs. 33.8%). Based on interviews, the top complaint/ disease in both areas was hypertension. The number of subjects who were diagnosed with hypertension were 23 (33,82%) and 30 (32,97%) from Bantar Kulon and Kronggahan respectively. Impaired fasting glucose was more common in Bantar Kulon (rural area) while hypertension is more common in Kronggahan (urban area). The main complaint / disease in both regions is hypertension.KEYWORDS blood glucose; metabolic syndrome; hypertension; rural area; urban area

This classroom action research aims to increase interest and learning outcomes using the whatsapp group application in the subject of the activity sub-theme in the afternoon of first graders at SDn Kajar. The research subjects were 26 students. Data collection techniques using the method of test, observation and documentation. The data validation technique uses source triangulation. Data analysis used descriptive qualitative technique. The students' learning interest in the initial condition was 9 students or 34.62%, to 65.38% or 17 students, and 92.31% or 24 students in the second cycle. The average value of the initial conditions was 59.62 increased to 68.33, and 78.08 in the second cycle, while the level of mastery learning from 8 students or 30.77% to 16 students or 61.54% and 23 students or 88, 46% in the second cycle. This increase in learning outcomes can not be separated from the skills of teachers and students' interests. Referring to the research indicators, namely 85% of students experienced individual learning completeness 70, the research was declared successful.

Menyusun bahar ajar merupakan salah satu kompetensi penting yang harus dimiliki oleh semua guru, terlebih guru-guru yang telah mendapatkan sertifikasi. Namun realita di lapangan di SD negeri 117 Rejang Lebong, kemampuan guru dalam menyusun bahar ajar sangat rendah dan perlu ditingkatkan. Penelitan ini dilaksanakan dengan tujuan untuk meningkatkan kompetensi pedagogic guru, khususnya dalam menyusun bahan ajar berbasis kearifan lokal melalui Program In House Training yang dilakukan oleh Kepala Sekolah. Penelitian ini dilakukan menggunakan maetode Penelitian Tindakan Sekolah atau PTS dengan total dua siklus. Berdasarkan penelitian yang dilakukan diperoleh hasil bahwa program In House Training yang dilakukan oleh Kepala Sekolah selama dua siklus terbukti dapat meningkatkan kemampuan guru dalam menyusun bahan ajar berbasis kearifan lokal di SD Negeri 117 Rejang Lebong. Adapun rincian hasilnnya ialah: 1) item kesesuaian tema dengan kompetensi dasar meningkat dari 72,85 menjadi 85; 2) item petunjuk penggunaan bahan ajar meningkat dari 75 menjadi 90; 3) item bahasa meningkat dari 60 menjadi 80; 4) itiem desain dan tampilan meningkat dai 69 menjadi 80; dan 5) item evaluasi meningkat dari 77 menjadi 90.